Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.

The mean electrophoretic mobility (EPM) of splenic cells was determined in 4 different host-tumour systems. In splenic cells harvested from mice bearing slow-growing tumours, a significant EPM decrease was observed (12%) and in increase in the proportion of cells with slow mobility. Moreover, after...

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Detalles Bibliográficos
Autores principales: Vaillier, D., Vaillier, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010537/
https://www.ncbi.nlm.nih.gov/pubmed/7459209
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author Vaillier, D.
Vaillier, J.
author_facet Vaillier, D.
Vaillier, J.
author_sort Vaillier, D.
collection PubMed
description The mean electrophoretic mobility (EPM) of splenic cells was determined in 4 different host-tumour systems. In splenic cells harvested from mice bearing slow-growing tumours, a significant EPM decrease was observed (12%) and in increase in the proportion of cells with slow mobility. Moreover, after 1 h incubation in RPMI medium at 37 degrees C and 2 washings, spleen cells showed a marked increase in their EPM (average 30%). Finally, the supernatant from incubation medium after contact with normal spleen cells (1 h at 37 degrees C) produced a significant decrease in their EPM (approximately 12%). On the other hand, no significant EPM variations were found between control spleen cells and cells from fast-growing tumours, before or after 1h incubation. The existence of factors which induce a loss of negative surface charge on spleen cells of some tumour-grafted mice is discussed.
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spelling pubmed-20105372009-09-10 Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour. Vaillier, D. Vaillier, J. Br J Cancer Research Article The mean electrophoretic mobility (EPM) of splenic cells was determined in 4 different host-tumour systems. In splenic cells harvested from mice bearing slow-growing tumours, a significant EPM decrease was observed (12%) and in increase in the proportion of cells with slow mobility. Moreover, after 1 h incubation in RPMI medium at 37 degrees C and 2 washings, spleen cells showed a marked increase in their EPM (average 30%). Finally, the supernatant from incubation medium after contact with normal spleen cells (1 h at 37 degrees C) produced a significant decrease in their EPM (approximately 12%). On the other hand, no significant EPM variations were found between control spleen cells and cells from fast-growing tumours, before or after 1h incubation. The existence of factors which induce a loss of negative surface charge on spleen cells of some tumour-grafted mice is discussed. Nature Publishing Group 1980-11 /pmc/articles/PMC2010537/ /pubmed/7459209 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Vaillier, D.
Vaillier, J.
Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.
title Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.
title_full Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.
title_fullStr Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.
title_full_unstemmed Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.
title_short Factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.
title_sort factors inducing a loss of net negative surface charge on spleen cells of mice grafted with a slow-growing tumour.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010537/
https://www.ncbi.nlm.nih.gov/pubmed/7459209
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