Survival of intestinal crypts after treatment by adriamycin alone or with radiation.

A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) co...

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Detalles Bibliográficos
Autores principales: Moore, J. V., Broadbent, D. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010542/
https://www.ncbi.nlm.nih.gov/pubmed/7459206
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author Moore, J. V.
Broadbent, D. A.
author_facet Moore, J. V.
Broadbent, D. A.
author_sort Moore, J. V.
collection PubMed
description A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) compared to the value for gamma radiation. This observation is discussed with respect to the interpretation of crypt survival curves. We were unable to demonstrate any enhancement by adriamycin (reduction in Dq) of the response of microcolony-forming cells to radiation given immediately before the drug.
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spelling pubmed-20105422009-09-10 Survival of intestinal crypts after treatment by adriamycin alone or with radiation. Moore, J. V. Broadbent, D. A. Br J Cancer Research Article A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) compared to the value for gamma radiation. This observation is discussed with respect to the interpretation of crypt survival curves. We were unable to demonstrate any enhancement by adriamycin (reduction in Dq) of the response of microcolony-forming cells to radiation given immediately before the drug. Nature Publishing Group 1980-11 /pmc/articles/PMC2010542/ /pubmed/7459206 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Moore, J. V.
Broadbent, D. A.
Survival of intestinal crypts after treatment by adriamycin alone or with radiation.
title Survival of intestinal crypts after treatment by adriamycin alone or with radiation.
title_full Survival of intestinal crypts after treatment by adriamycin alone or with radiation.
title_fullStr Survival of intestinal crypts after treatment by adriamycin alone or with radiation.
title_full_unstemmed Survival of intestinal crypts after treatment by adriamycin alone or with radiation.
title_short Survival of intestinal crypts after treatment by adriamycin alone or with radiation.
title_sort survival of intestinal crypts after treatment by adriamycin alone or with radiation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010542/
https://www.ncbi.nlm.nih.gov/pubmed/7459206
work_keys_str_mv AT moorejv survivalofintestinalcryptsaftertreatmentbyadriamycinaloneorwithradiation
AT broadbentda survivalofintestinalcryptsaftertreatmentbyadriamycinaloneorwithradiation

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