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Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer.
The concentration of the common alpha subunit of the glycoprotein hormones was high in the serum of 21/56 (38%) of premenopausal patients and 22/106 (21%) of postmenopausal patients with primary breast cancer, at the time of presentation. 7/59 (12%) of patients with benign disease also had high alph...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1980
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010551/ https://www.ncbi.nlm.nih.gov/pubmed/6161628 |
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author | MacFarlane, I. A. Barnes, D. Howat, J. M. Swindell, R. Durning, P. Beardwell, C. G. Bush, H. Sellwood, R. A. |
author_facet | MacFarlane, I. A. Barnes, D. Howat, J. M. Swindell, R. Durning, P. Beardwell, C. G. Bush, H. Sellwood, R. A. |
author_sort | MacFarlane, I. A. |
collection | PubMed |
description | The concentration of the common alpha subunit of the glycoprotein hormones was high in the serum of 21/56 (38%) of premenopausal patients and 22/106 (21%) of postmenopausal patients with primary breast cancer, at the time of presentation. 7/59 (12%) of patients with benign disease also had high alpha subunit levels. Tumour cytosol oestrogen and progesterone receptor status was determined in 80% of the patients with cancer, and there was a trend towards higher alpha levels in patients without receptors, but this was not statistically significant. In the premenopausal patients with cancer there was a significant correlation between alpha subunit level and disease stage, R = 0.47, P = 0.0001, but not in the postmenopausal patients. In view of the correlation with disease stage, high levels of alpha subunit in premenopausal patients with breast cancer at presentation with the primary tumour may indicate poor prognosis. |
format | Text |
id | pubmed-2010551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1980 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20105512009-09-10 Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. MacFarlane, I. A. Barnes, D. Howat, J. M. Swindell, R. Durning, P. Beardwell, C. G. Bush, H. Sellwood, R. A. Br J Cancer Research Article The concentration of the common alpha subunit of the glycoprotein hormones was high in the serum of 21/56 (38%) of premenopausal patients and 22/106 (21%) of postmenopausal patients with primary breast cancer, at the time of presentation. 7/59 (12%) of patients with benign disease also had high alpha subunit levels. Tumour cytosol oestrogen and progesterone receptor status was determined in 80% of the patients with cancer, and there was a trend towards higher alpha levels in patients without receptors, but this was not statistically significant. In the premenopausal patients with cancer there was a significant correlation between alpha subunit level and disease stage, R = 0.47, P = 0.0001, but not in the postmenopausal patients. In view of the correlation with disease stage, high levels of alpha subunit in premenopausal patients with breast cancer at presentation with the primary tumour may indicate poor prognosis. Nature Publishing Group 1980-11 /pmc/articles/PMC2010551/ /pubmed/6161628 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article MacFarlane, I. A. Barnes, D. Howat, J. M. Swindell, R. Durning, P. Beardwell, C. G. Bush, H. Sellwood, R. A. Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. |
title | Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. |
title_full | Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. |
title_fullStr | Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. |
title_full_unstemmed | Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. |
title_short | Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. |
title_sort | serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010551/ https://www.ncbi.nlm.nih.gov/pubmed/6161628 |
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