Characterization of human sarcoma antigen S3.

An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amoun...

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Autores principales: Sethi, J. K., Hirshaut, Y.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010596/
https://www.ncbi.nlm.nih.gov/pubmed/6164380
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author Sethi, J. K.
Hirshaut, Y.
author_facet Sethi, J. K.
Hirshaut, Y.
author_sort Sethi, J. K.
collection PubMed
description An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP there is no correlation between S3 antigen and the presence or amount of these known tumour-associated substances. S3 antibody can be fully absorbed with guinea-pig kidney but not boiled beef or SRBC. S3, therefore, is a heterophile substance which has not previously been identified. A seroepidemiological survey confirms that S3-antibody prevalence is significantly increased in persons with a wide variety of malignant disease, as well as in family members of patients with sarcoma.
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spelling pubmed-20105962009-09-10 Characterization of human sarcoma antigen S3. Sethi, J. K. Hirshaut, Y. Br J Cancer Research Article An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP there is no correlation between S3 antigen and the presence or amount of these known tumour-associated substances. S3 antibody can be fully absorbed with guinea-pig kidney but not boiled beef or SRBC. S3, therefore, is a heterophile substance which has not previously been identified. A seroepidemiological survey confirms that S3-antibody prevalence is significantly increased in persons with a wide variety of malignant disease, as well as in family members of patients with sarcoma. Nature Publishing Group 1981-03 /pmc/articles/PMC2010596/ /pubmed/6164380 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sethi, J. K.
Hirshaut, Y.
Characterization of human sarcoma antigen S3.
title Characterization of human sarcoma antigen S3.
title_full Characterization of human sarcoma antigen S3.
title_fullStr Characterization of human sarcoma antigen S3.
title_full_unstemmed Characterization of human sarcoma antigen S3.
title_short Characterization of human sarcoma antigen S3.
title_sort characterization of human sarcoma antigen s3.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010596/
https://www.ncbi.nlm.nih.gov/pubmed/6164380
work_keys_str_mv AT sethijk characterizationofhumansarcomaantigens3
AT hirshauty characterizationofhumansarcomaantigens3

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