Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.

Polyamines, such as putrescine and spermine, are naturally occurring substances intimately associated with normal and neoplastic growth. High levels are found in cancer patients and are associated with tumour growth. Experiments with V79 hamster cells cultured in vitro have demonstrated that the pre...

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Autor principal: Roizin-Towle, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010601/
https://www.ncbi.nlm.nih.gov/pubmed/7194685
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author Roizin-Towle, L.
author_facet Roizin-Towle, L.
author_sort Roizin-Towle, L.
collection PubMed
description Polyamines, such as putrescine and spermine, are naturally occurring substances intimately associated with normal and neoplastic growth. High levels are found in cancer patients and are associated with tumour growth. Experiments with V79 hamster cells cultured in vitro have demonstrated that the presence of putrescine and spermine can significantly reduce the cytotoxicity of the commonly used chemotherapy agent cis-DDP. These data may have clinical implications.
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spelling pubmed-20106012009-09-10 Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture. Roizin-Towle, L. Br J Cancer Research Article Polyamines, such as putrescine and spermine, are naturally occurring substances intimately associated with normal and neoplastic growth. High levels are found in cancer patients and are associated with tumour growth. Experiments with V79 hamster cells cultured in vitro have demonstrated that the presence of putrescine and spermine can significantly reduce the cytotoxicity of the commonly used chemotherapy agent cis-DDP. These data may have clinical implications. Nature Publishing Group 1981-03 /pmc/articles/PMC2010601/ /pubmed/7194685 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Roizin-Towle, L.
Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.
title Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.
title_full Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.
title_fullStr Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.
title_full_unstemmed Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.
title_short Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.
title_sort studies with cis-diamminedichloro-platinum ii and exogenous polyamines using mammalian cells in culture.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010601/
https://www.ncbi.nlm.nih.gov/pubmed/7194685
work_keys_str_mv AT roizintowlel studieswithcisdiamminedichloroplatinumiiandexogenouspolyaminesusingmammaliancellsinculture

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