Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines.

The effect of various mediators on the growth and secretion of IgE by two human myeloma cell lines derived originally from the same tumour was tested. It was found that the growth of U266 was unaffected by PGE2, but IgE secretion was blocked. PGF2 alpha, whilst inhibiting growth, had little effect o...

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Detalles Bibliográficos
Autores principales: Carini, C., Hudspith, B. N., Brostoff, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010606/
https://www.ncbi.nlm.nih.gov/pubmed/7225278
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author Carini, C.
Hudspith, B. N.
Brostoff, J.
author_facet Carini, C.
Hudspith, B. N.
Brostoff, J.
author_sort Carini, C.
collection PubMed
description The effect of various mediators on the growth and secretion of IgE by two human myeloma cell lines derived originally from the same tumour was tested. It was found that the growth of U266 was unaffected by PGE2, but IgE secretion was blocked. PGF2 alpha, whilst inhibiting growth, had little effect on IgE secretion. With the second cell line, U266 BL, it was found that none of the agents tested could modulate the secretion of IgE, though cell growth was blocked by PGE2. Prostaglandins act by modulating cyclic nucleotides, the E series increasing the level of cAMP and the F series causing a rise in cGMP. Our findings with prostaglandins could be mimicked by the relevant cyclic nucleotide. Possible explanations for these differences are discussed.
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spelling pubmed-20106062009-09-10 Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines. Carini, C. Hudspith, B. N. Brostoff, J. Br J Cancer Research Article The effect of various mediators on the growth and secretion of IgE by two human myeloma cell lines derived originally from the same tumour was tested. It was found that the growth of U266 was unaffected by PGE2, but IgE secretion was blocked. PGF2 alpha, whilst inhibiting growth, had little effect on IgE secretion. With the second cell line, U266 BL, it was found that none of the agents tested could modulate the secretion of IgE, though cell growth was blocked by PGE2. Prostaglandins act by modulating cyclic nucleotides, the E series increasing the level of cAMP and the F series causing a rise in cGMP. Our findings with prostaglandins could be mimicked by the relevant cyclic nucleotide. Possible explanations for these differences are discussed. Nature Publishing Group 1981-03 /pmc/articles/PMC2010606/ /pubmed/7225278 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Carini, C.
Hudspith, B. N.
Brostoff, J.
Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines.
title Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines.
title_full Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines.
title_fullStr Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines.
title_full_unstemmed Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines.
title_short Effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two IgE myeloma cell lines.
title_sort effect of prostaglandins and cyclic nucleotides on growth and immunoglobulin secretion of two ige myeloma cell lines.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010606/
https://www.ncbi.nlm.nih.gov/pubmed/7225278
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AT brostoffj effectofprostaglandinsandcyclicnucleotidesongrowthandimmunoglobulinsecretionoftwoigemyelomacelllines

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