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Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts.
The effect of melphalan on the growth of 4 different lines of human lung-tumour xenografts has been established. The oat-cell carcinoma was the most sensitive, whereas the adenocarcinoma was the most resistant. Two lines of large-cell anaplastic carcinomas were intermediate in sensitivity. The diffe...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1981
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010633/ https://www.ncbi.nlm.nih.gov/pubmed/6263305 |
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author | Wist, E. Millar, J. L. Shorthouse, A. J. |
author_facet | Wist, E. Millar, J. L. Shorthouse, A. J. |
author_sort | Wist, E. |
collection | PubMed |
description | The effect of melphalan on the growth of 4 different lines of human lung-tumour xenografts has been established. The oat-cell carcinoma was the most sensitive, whereas the adenocarcinoma was the most resistant. Two lines of large-cell anaplastic carcinomas were intermediate in sensitivity. The differences in sensitivity were not reflected in the gross uptake of drug into the tumours. There was, with the exception of the adenocarcinoma line, a marked decrease in uptake per g tumour with increasing tumour size. This was partly caused by a decrease in the vascular supply in the same tumours with increasing tumour size. Extravasation of plasma proteins increased with increasing tumour size in all tumours, but was much less pronounced in the adenocarcinoma than in the other tumour lines. The extracellular volume of the various tumour lines did not vary with tumour size. |
format | Text |
id | pubmed-2010633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20106332009-09-10 Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. Wist, E. Millar, J. L. Shorthouse, A. J. Br J Cancer Research Article The effect of melphalan on the growth of 4 different lines of human lung-tumour xenografts has been established. The oat-cell carcinoma was the most sensitive, whereas the adenocarcinoma was the most resistant. Two lines of large-cell anaplastic carcinomas were intermediate in sensitivity. The differences in sensitivity were not reflected in the gross uptake of drug into the tumours. There was, with the exception of the adenocarcinoma line, a marked decrease in uptake per g tumour with increasing tumour size. This was partly caused by a decrease in the vascular supply in the same tumours with increasing tumour size. Extravasation of plasma proteins increased with increasing tumour size in all tumours, but was much less pronounced in the adenocarcinoma than in the other tumour lines. The extracellular volume of the various tumour lines did not vary with tumour size. Nature Publishing Group 1981-04 /pmc/articles/PMC2010633/ /pubmed/6263305 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Wist, E. Millar, J. L. Shorthouse, A. J. Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. |
title | Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. |
title_full | Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. |
title_fullStr | Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. |
title_full_unstemmed | Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. |
title_short | Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. |
title_sort | melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010633/ https://www.ncbi.nlm.nih.gov/pubmed/6263305 |
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