A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.

The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No signi...

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Detalles Bibliográficos
Autores principales: Bleehen, N. M., Wiltshire, C. R., Plowman, P. N., Watson, J. V., Gleave, J. R., Holmes, A. E., Lewin, W. S., Treip, C. S., Hawkins, T. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010639/
https://www.ncbi.nlm.nih.gov/pubmed/7016157
Descripción
Sumario:The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail.

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