A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.

The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No signi...

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Autores principales: Bleehen, N. M., Wiltshire, C. R., Plowman, P. N., Watson, J. V., Gleave, J. R., Holmes, A. E., Lewin, W. S., Treip, C. S., Hawkins, T. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010639/
https://www.ncbi.nlm.nih.gov/pubmed/7016157
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author Bleehen, N. M.
Wiltshire, C. R.
Plowman, P. N.
Watson, J. V.
Gleave, J. R.
Holmes, A. E.
Lewin, W. S.
Treip, C. S.
Hawkins, T. D.
author_facet Bleehen, N. M.
Wiltshire, C. R.
Plowman, P. N.
Watson, J. V.
Gleave, J. R.
Holmes, A. E.
Lewin, W. S.
Treip, C. S.
Hawkins, T. D.
author_sort Bleehen, N. M.
collection PubMed
description The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail.
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spelling pubmed-20106392009-09-10 A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. Bleehen, N. M. Wiltshire, C. R. Plowman, P. N. Watson, J. V. Gleave, J. R. Holmes, A. E. Lewin, W. S. Treip, C. S. Hawkins, T. D. Br J Cancer Research Article The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail. Nature Publishing Group 1981-04 /pmc/articles/PMC2010639/ /pubmed/7016157 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bleehen, N. M.
Wiltshire, C. R.
Plowman, P. N.
Watson, J. V.
Gleave, J. R.
Holmes, A. E.
Lewin, W. S.
Treip, C. S.
Hawkins, T. D.
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
title A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
title_full A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
title_fullStr A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
title_full_unstemmed A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
title_short A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
title_sort randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010639/
https://www.ncbi.nlm.nih.gov/pubmed/7016157
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