Combination therapy of a mouse sarcoma using razoxane and electron irradiation.

The combination of a single dose of razoxane (ICRF 159) with a single dose of electron radiation has been studied with the murine sarcoma S180. A drug dose of 30 mg/kg combined with radiation produced a greater tumour response than either agent alone, but it was not possible to establish whether the...

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Autores principales: Grimshaw, M. B., Davies, R. W., Hall, W. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010644/
https://www.ncbi.nlm.nih.gov/pubmed/7259958
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author Grimshaw, M. B.
Davies, R. W.
Hall, W. S.
author_facet Grimshaw, M. B.
Davies, R. W.
Hall, W. S.
author_sort Grimshaw, M. B.
collection PubMed
description The combination of a single dose of razoxane (ICRF 159) with a single dose of electron radiation has been studied with the murine sarcoma S180. A drug dose of 30 mg/kg combined with radiation produced a greater tumour response than either agent alone, but it was not possible to establish whether the effect was more than additive. Direct measurements of tumour and s.c. oxygen concentrations and studies of tumour-cell respiration were carried out after various razoxane treatments in an attempt to elucidate mechanisms of action. There were no indications at the drug dose levels used in the radiation studies of any significant changes in tissue oxygenation or cellular respiration.
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spelling pubmed-20106442009-09-10 Combination therapy of a mouse sarcoma using razoxane and electron irradiation. Grimshaw, M. B. Davies, R. W. Hall, W. S. Br J Cancer Research Article The combination of a single dose of razoxane (ICRF 159) with a single dose of electron radiation has been studied with the murine sarcoma S180. A drug dose of 30 mg/kg combined with radiation produced a greater tumour response than either agent alone, but it was not possible to establish whether the effect was more than additive. Direct measurements of tumour and s.c. oxygen concentrations and studies of tumour-cell respiration were carried out after various razoxane treatments in an attempt to elucidate mechanisms of action. There were no indications at the drug dose levels used in the radiation studies of any significant changes in tissue oxygenation or cellular respiration. Nature Publishing Group 1981-07 /pmc/articles/PMC2010644/ /pubmed/7259958 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Grimshaw, M. B.
Davies, R. W.
Hall, W. S.
Combination therapy of a mouse sarcoma using razoxane and electron irradiation.
title Combination therapy of a mouse sarcoma using razoxane and electron irradiation.
title_full Combination therapy of a mouse sarcoma using razoxane and electron irradiation.
title_fullStr Combination therapy of a mouse sarcoma using razoxane and electron irradiation.
title_full_unstemmed Combination therapy of a mouse sarcoma using razoxane and electron irradiation.
title_short Combination therapy of a mouse sarcoma using razoxane and electron irradiation.
title_sort combination therapy of a mouse sarcoma using razoxane and electron irradiation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010644/
https://www.ncbi.nlm.nih.gov/pubmed/7259958
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AT hallws combinationtherapyofamousesarcomausingrazoxaneandelectronirradiation

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