Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.

Using the data described in Paper I, we compare the effects of the same treatment timings and doses given at different ages. Initiation with DMBA at 68 weeks of age, followed 3 weeks later by TPA, has a significantly (P less than 0.0001) less rapid effect on subsequent tumour incidence than does ini...

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Detalles Bibliográficos
Autores principales: Stenbäck, F., Peto, R., Shubik, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010654/
https://www.ncbi.nlm.nih.gov/pubmed/6789854
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author Stenbäck, F.
Peto, R.
Shubik, P.
author_facet Stenbäck, F.
Peto, R.
Shubik, P.
author_sort Stenbäck, F.
collection PubMed
description Using the data described in Paper I, we compare the effects of the same treatment timings and doses given at different ages. Initiation with DMBA at 68 weeks of age, followed 3 weeks later by TPA, has a significantly (P less than 0.0001) less rapid effect on subsequent tumour incidence than does initiation at 8 or at 48 weeks of age, followed 3 weeks later by TPA. We suggested that this is chiefly due not to changes in the numbers of cells initiated by DMBA, but rather to a decrease in the promotional efficacy of TPA in ageing mice.
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spelling pubmed-20106542009-09-10 Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing. Stenbäck, F. Peto, R. Shubik, P. Br J Cancer Research Article Using the data described in Paper I, we compare the effects of the same treatment timings and doses given at different ages. Initiation with DMBA at 68 weeks of age, followed 3 weeks later by TPA, has a significantly (P less than 0.0001) less rapid effect on subsequent tumour incidence than does initiation at 8 or at 48 weeks of age, followed 3 weeks later by TPA. We suggested that this is chiefly due not to changes in the numbers of cells initiated by DMBA, but rather to a decrease in the promotional efficacy of TPA in ageing mice. Nature Publishing Group 1981-07 /pmc/articles/PMC2010654/ /pubmed/6789854 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Stenbäck, F.
Peto, R.
Shubik, P.
Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
title Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
title_full Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
title_fullStr Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
title_full_unstemmed Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
title_short Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
title_sort initiation and promotion at different ages and doses in 2200 mice. ii. decrease in promotion by tpa with ageing.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010654/
https://www.ncbi.nlm.nih.gov/pubmed/6789854
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