Increased tissue histamine in tumour-bearing mice and rats.

Tissue histamine levels were studied in C3H and C57BL/6 mice bearing a methylcholanthrene-induced fibrosarcoma, in Wag rats bearing an aflatoxin B1-induced hepatoma, and in Commentry rats bearing a grafted hepatoma. Histamine levels were significantly higher (1.5 to 3 fold) in the tumour-bearing ani...

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Autores principales: Burtin, C., Scheinmann, P., Salomon, J. C., Lespinats, G., Frayssinet, C., Lebel, B., Canu, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010678/
https://www.ncbi.nlm.nih.gov/pubmed/7248152
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author Burtin, C.
Scheinmann, P.
Salomon, J. C.
Lespinats, G.
Frayssinet, C.
Lebel, B.
Canu, P.
author_facet Burtin, C.
Scheinmann, P.
Salomon, J. C.
Lespinats, G.
Frayssinet, C.
Lebel, B.
Canu, P.
author_sort Burtin, C.
collection PubMed
description Tissue histamine levels were studied in C3H and C57BL/6 mice bearing a methylcholanthrene-induced fibrosarcoma, in Wag rats bearing an aflatoxin B1-induced hepatoma, and in Commentry rats bearing a grafted hepatoma. Histamine levels were significantly higher (1.5 to 3 fold) in the tumour-bearing animals for ventral and dorsal skin, skeletal muscle and stomach fundus. Total histamine content was increased in the spleen. In C3H mice with McC3-1 fibrosarcoma, the excision of the tumour or its partial regression by intratumoral injections of corynebacterium parvum induced a reversion to normal values. The tumour thus appears responsible for the increased histamine levels in tissues distant from the tumour.
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spelling pubmed-20106782009-09-10 Increased tissue histamine in tumour-bearing mice and rats. Burtin, C. Scheinmann, P. Salomon, J. C. Lespinats, G. Frayssinet, C. Lebel, B. Canu, P. Br J Cancer Research Article Tissue histamine levels were studied in C3H and C57BL/6 mice bearing a methylcholanthrene-induced fibrosarcoma, in Wag rats bearing an aflatoxin B1-induced hepatoma, and in Commentry rats bearing a grafted hepatoma. Histamine levels were significantly higher (1.5 to 3 fold) in the tumour-bearing animals for ventral and dorsal skin, skeletal muscle and stomach fundus. Total histamine content was increased in the spleen. In C3H mice with McC3-1 fibrosarcoma, the excision of the tumour or its partial regression by intratumoral injections of corynebacterium parvum induced a reversion to normal values. The tumour thus appears responsible for the increased histamine levels in tissues distant from the tumour. Nature Publishing Group 1981-05 /pmc/articles/PMC2010678/ /pubmed/7248152 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Burtin, C.
Scheinmann, P.
Salomon, J. C.
Lespinats, G.
Frayssinet, C.
Lebel, B.
Canu, P.
Increased tissue histamine in tumour-bearing mice and rats.
title Increased tissue histamine in tumour-bearing mice and rats.
title_full Increased tissue histamine in tumour-bearing mice and rats.
title_fullStr Increased tissue histamine in tumour-bearing mice and rats.
title_full_unstemmed Increased tissue histamine in tumour-bearing mice and rats.
title_short Increased tissue histamine in tumour-bearing mice and rats.
title_sort increased tissue histamine in tumour-bearing mice and rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010678/
https://www.ncbi.nlm.nih.gov/pubmed/7248152
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