Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.

The synthesis of pregnancy-specific beta 1-glycoprotein (SP1) was studied in normal brain-derived and malignant glial-cell cultures. The normal brain-derived and glioma cells were found to contain SP1 when studied by radioimmunoassay and by the triple-bridge immunoperoxidase technique. The active sy...

Descripción completa

Detalles Bibliográficos
Autores principales: Heikinheimo, M., Paasivuo, R., Wahlström, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010680/
https://www.ncbi.nlm.nih.gov/pubmed/7018548
_version_ 1782136373025701888
author Heikinheimo, M.
Paasivuo, R.
Wahlström, T.
author_facet Heikinheimo, M.
Paasivuo, R.
Wahlström, T.
author_sort Heikinheimo, M.
collection PubMed
description The synthesis of pregnancy-specific beta 1-glycoprotein (SP1) was studied in normal brain-derived and malignant glial-cell cultures. The normal brain-derived and glioma cells were found to contain SP1 when studied by radioimmunoassay and by the triple-bridge immunoperoxidase technique. The active synthesis of SP1 by these brain-derived cells was confirmed by metabolic labelling and subsequent immune precipitation of the culture medium. The SP1-like material produced by the brain-derived cells had the same molecular weight as purified placental SP1. IMAGES:
format Text
id pubmed-2010680
institution National Center for Biotechnology Information
language English
publishDate 1981
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20106802009-09-10 Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro. Heikinheimo, M. Paasivuo, R. Wahlström, T. Br J Cancer Research Article The synthesis of pregnancy-specific beta 1-glycoprotein (SP1) was studied in normal brain-derived and malignant glial-cell cultures. The normal brain-derived and glioma cells were found to contain SP1 when studied by radioimmunoassay and by the triple-bridge immunoperoxidase technique. The active synthesis of SP1 by these brain-derived cells was confirmed by metabolic labelling and subsequent immune precipitation of the culture medium. The SP1-like material produced by the brain-derived cells had the same molecular weight as purified placental SP1. IMAGES: Nature Publishing Group 1981-05 /pmc/articles/PMC2010680/ /pubmed/7018548 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Heikinheimo, M.
Paasivuo, R.
Wahlström, T.
Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.
title Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.
title_full Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.
title_fullStr Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.
title_full_unstemmed Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.
title_short Cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.
title_sort cells from normal brain and gliomas synthesize pregnancy-specific beta 1-glycoprotein-like material in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010680/
https://www.ncbi.nlm.nih.gov/pubmed/7018548
work_keys_str_mv AT heikinheimom cellsfromnormalbrainandgliomassynthesizepregnancyspecificbeta1glycoproteinlikematerialinvitro
AT paasivuor cellsfromnormalbrainandgliomassynthesizepregnancyspecificbeta1glycoproteinlikematerialinvitro
AT wahlstromt cellsfromnormalbrainandgliomassynthesizepregnancyspecificbeta1glycoproteinlikematerialinvitro

Ejemplares similares