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Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.

Evidence is presented that microscopic tumours (of a transplantable murine mammary carcinoma, M8013X) grow faster than larger, palpable, tumours. Microscopic tumours are also more radiosensitive than larger tumours. The decrease in radiosensitivity in larger tumours is prevented to a large extent by...

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Autores principales: Haveman, J., Jansen, W., van der Schueren, E., Breur, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010718/
https://www.ncbi.nlm.nih.gov/pubmed/7248162
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author Haveman, J.
Jansen, W.
van der Schueren, E.
Breur, K.
author_facet Haveman, J.
Jansen, W.
van der Schueren, E.
Breur, K.
author_sort Haveman, J.
collection PubMed
description Evidence is presented that microscopic tumours (of a transplantable murine mammary carcinoma, M8013X) grow faster than larger, palpable, tumours. Microscopic tumours are also more radiosensitive than larger tumours. The decrease in radiosensitivity in larger tumours is prevented to a large extent by misonidazole, which has no significant effect on the radiosensitivity of microscopic tumours. The retardation in growth rate which occurs after the fast microscopic growth is probably related to the appearance of hypoxic cells. Both the decrease in growth rate and the progressive development of hypoxia may be caused by the relatively poorer blood flow in larger tumours. Part of the radioresistance in "large" tumours ( approximately 250 mm3) seems to be due to factors other than hypoxia; maybe cell-kinetic factors also play a role. The intrinsic radiosensitivity of tumour cells in microscopic tumours was assessed by means of a modified latency test: the Dq and Do were 2.2 and 2.5 Gy respectively. A number of factors which may influence the reliability of these estimates are discussed.
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spelling pubmed-20107182009-09-10 Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice. Haveman, J. Jansen, W. van der Schueren, E. Breur, K. Br J Cancer Research Article Evidence is presented that microscopic tumours (of a transplantable murine mammary carcinoma, M8013X) grow faster than larger, palpable, tumours. Microscopic tumours are also more radiosensitive than larger tumours. The decrease in radiosensitivity in larger tumours is prevented to a large extent by misonidazole, which has no significant effect on the radiosensitivity of microscopic tumours. The retardation in growth rate which occurs after the fast microscopic growth is probably related to the appearance of hypoxic cells. Both the decrease in growth rate and the progressive development of hypoxia may be caused by the relatively poorer blood flow in larger tumours. Part of the radioresistance in "large" tumours ( approximately 250 mm3) seems to be due to factors other than hypoxia; maybe cell-kinetic factors also play a role. The intrinsic radiosensitivity of tumour cells in microscopic tumours was assessed by means of a modified latency test: the Dq and Do were 2.2 and 2.5 Gy respectively. A number of factors which may influence the reliability of these estimates are discussed. Nature Publishing Group 1981-06 /pmc/articles/PMC2010718/ /pubmed/7248162 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Haveman, J.
Jansen, W.
van der Schueren, E.
Breur, K.
Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.
title Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.
title_full Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.
title_fullStr Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.
title_full_unstemmed Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.
title_short Radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.
title_sort radiosensitivity of microscopic tumours of a transplantable mammary adenocarcinoma in mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010718/
https://www.ncbi.nlm.nih.gov/pubmed/7248162
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