Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.

Ten cell lines of human squamous carcinomas of the tongue and larynx have been established from surgical specimens removed from 36 unselected patients, in order to provide systems for investigating the invasive and tissue-destructive capacity of squamous carcinomas of the head and neck. The morpholo...

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Autores principales: Easty, D. M., Easty, G. C., Carter, R. L., Monaghan, P., Butler, L. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010719/
https://www.ncbi.nlm.nih.gov/pubmed/7195729
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author Easty, D. M.
Easty, G. C.
Carter, R. L.
Monaghan, P.
Butler, L. J.
author_facet Easty, D. M.
Easty, G. C.
Carter, R. L.
Monaghan, P.
Butler, L. J.
author_sort Easty, D. M.
collection PubMed
description Ten cell lines of human squamous carcinomas of the tongue and larynx have been established from surgical specimens removed from 36 unselected patients, in order to provide systems for investigating the invasive and tissue-destructive capacity of squamous carcinomas of the head and neck. The morphology, ultrastructure and growth characteristics of the 10 lines are described. Detailed cytogenetic analysis of the first 4 lines indicates that each is karyotypically unique, with no evidence of cross-contamination. Nine of the 10 cell lines secrete immunoreactive beta human chorionic gonadotrophin (beta-hCG) in the culture medium. No correlation was demonstrated between the ability of the cell lines to secrete plasminogen activator and their capacity to grow in soft agar or as xenografts in immune-deficient mice. IMAGES:
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spelling pubmed-20107192009-09-10 Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck. Easty, D. M. Easty, G. C. Carter, R. L. Monaghan, P. Butler, L. J. Br J Cancer Research Article Ten cell lines of human squamous carcinomas of the tongue and larynx have been established from surgical specimens removed from 36 unselected patients, in order to provide systems for investigating the invasive and tissue-destructive capacity of squamous carcinomas of the head and neck. The morphology, ultrastructure and growth characteristics of the 10 lines are described. Detailed cytogenetic analysis of the first 4 lines indicates that each is karyotypically unique, with no evidence of cross-contamination. Nine of the 10 cell lines secrete immunoreactive beta human chorionic gonadotrophin (beta-hCG) in the culture medium. No correlation was demonstrated between the ability of the cell lines to secrete plasminogen activator and their capacity to grow in soft agar or as xenografts in immune-deficient mice. IMAGES: Nature Publishing Group 1981-06 /pmc/articles/PMC2010719/ /pubmed/7195729 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Easty, D. M.
Easty, G. C.
Carter, R. L.
Monaghan, P.
Butler, L. J.
Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
title Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
title_full Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
title_fullStr Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
title_full_unstemmed Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
title_short Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
title_sort ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010719/
https://www.ncbi.nlm.nih.gov/pubmed/7195729
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