Reduction of daunomycin toxicity by razoxane.

A single dose of 200 mg/kg razoxane protected mice against the subchronic lethal effects (i.e. within 21 days) of 10 mg/kg daunomycin. When the razoxane dose was split into 2 doses of 100 mg/kg, even better protection against higher doses of daunomycin was obtained. The best protective effect was se...

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Detalles Bibliográficos
Autores principales: Wang, G., Finch, M. D., Trevan, D., Hellmann, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010720/
https://www.ncbi.nlm.nih.gov/pubmed/7248163
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author Wang, G.
Finch, M. D.
Trevan, D.
Hellmann, K.
author_facet Wang, G.
Finch, M. D.
Trevan, D.
Hellmann, K.
author_sort Wang, G.
collection PubMed
description A single dose of 200 mg/kg razoxane protected mice against the subchronic lethal effects (i.e. within 21 days) of 10 mg/kg daunomycin. When the razoxane dose was split into 2 doses of 100 mg/kg, even better protection against higher doses of daunomycin was obtained. The best protective effect was seen when the razoxane was given 24 h before or simultaneously with the daunomycin, and it was still present, though less, 24 h later. Histopathological examination to determine the site of protection showed it to be in the small bowel. Marrow and cardiac tissue showed no evident changes when examined by light microscopy. IMAGES:
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spelling pubmed-20107202009-09-10 Reduction of daunomycin toxicity by razoxane. Wang, G. Finch, M. D. Trevan, D. Hellmann, K. Br J Cancer Research Article A single dose of 200 mg/kg razoxane protected mice against the subchronic lethal effects (i.e. within 21 days) of 10 mg/kg daunomycin. When the razoxane dose was split into 2 doses of 100 mg/kg, even better protection against higher doses of daunomycin was obtained. The best protective effect was seen when the razoxane was given 24 h before or simultaneously with the daunomycin, and it was still present, though less, 24 h later. Histopathological examination to determine the site of protection showed it to be in the small bowel. Marrow and cardiac tissue showed no evident changes when examined by light microscopy. IMAGES: Nature Publishing Group 1981-06 /pmc/articles/PMC2010720/ /pubmed/7248163 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wang, G.
Finch, M. D.
Trevan, D.
Hellmann, K.
Reduction of daunomycin toxicity by razoxane.
title Reduction of daunomycin toxicity by razoxane.
title_full Reduction of daunomycin toxicity by razoxane.
title_fullStr Reduction of daunomycin toxicity by razoxane.
title_full_unstemmed Reduction of daunomycin toxicity by razoxane.
title_short Reduction of daunomycin toxicity by razoxane.
title_sort reduction of daunomycin toxicity by razoxane.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010720/
https://www.ncbi.nlm.nih.gov/pubmed/7248163
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AT finchmd reductionofdaunomycintoxicitybyrazoxane
AT trevand reductionofdaunomycintoxicitybyrazoxane
AT hellmannk reductionofdaunomycintoxicitybyrazoxane

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