Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.

An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbe...

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Autores principales: Stevens, R. H., Cole, D. A., Cheng, H. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010725/
https://www.ncbi.nlm.nih.gov/pubmed/6788060
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author Stevens, R. H.
Cole, D. A.
Cheng, H. F.
author_facet Stevens, R. H.
Cole, D. A.
Cheng, H. F.
author_sort Stevens, R. H.
collection PubMed
description An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (pancreas). The oncofoetal protein was identified by the use of specific xenogenic antitumour rabbit sera generated to the X-ray-induced neoplasm. In addition, the foetal protein was also found always to occur in the liver and lungs of those animals bearing the chemically induced tumours as well as in their serum. These results suggest the existence of a close relationship at the molecular level in the tumorigenic processes, even though induction is by apparently different mechanisms, for cancers arising in tissue or common embryonic origin. IMAGES:
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spelling pubmed-20107252009-09-10 Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours. Stevens, R. H. Cole, D. A. Cheng, H. F. Br J Cancer Research Article An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (pancreas). The oncofoetal protein was identified by the use of specific xenogenic antitumour rabbit sera generated to the X-ray-induced neoplasm. In addition, the foetal protein was also found always to occur in the liver and lungs of those animals bearing the chemically induced tumours as well as in their serum. These results suggest the existence of a close relationship at the molecular level in the tumorigenic processes, even though induction is by apparently different mechanisms, for cancers arising in tissue or common embryonic origin. IMAGES: Nature Publishing Group 1981-06 /pmc/articles/PMC2010725/ /pubmed/6788060 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Stevens, R. H.
Cole, D. A.
Cheng, H. F.
Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
title Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
title_full Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
title_fullStr Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
title_full_unstemmed Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
title_short Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
title_sort identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010725/
https://www.ncbi.nlm.nih.gov/pubmed/6788060
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AT chenghf identificationofacommononcofoetalproteininxrayandchemicallyinducedratgastrointestinaltumours

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