Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.

Nuclear and cytoplasmic oestrogen receptors (REN and REC) were sought in 5 normal cervices and in 43 specimens of squamous carcinoma of the cervix. All 3 tissues components of the 5 normal cervices contained both REN and REC. Thirty-five (81%) of the tumours contained receptors, but in only 9 (21%)...

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Autores principales: Soutter, W. P., Pegoraro, R. J., Green-Thompson, R. W., Naidoo, D. V., Joubert, S. M., Philpott, R. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010733/
https://www.ncbi.nlm.nih.gov/pubmed/7272184
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author Soutter, W. P.
Pegoraro, R. J.
Green-Thompson, R. W.
Naidoo, D. V.
Joubert, S. M.
Philpott, R. H.
author_facet Soutter, W. P.
Pegoraro, R. J.
Green-Thompson, R. W.
Naidoo, D. V.
Joubert, S. M.
Philpott, R. H.
author_sort Soutter, W. P.
collection PubMed
description Nuclear and cytoplasmic oestrogen receptors (REN and REC) were sought in 5 normal cervices and in 43 specimens of squamous carcinoma of the cervix. All 3 tissues components of the 5 normal cervices contained both REN and REC. Thirty-five (81%) of the tumours contained receptors, but in only 9 (21%) were they found in both subcellular compartments. Twenty-four tumours (56%) had only REC and 2 had only REN. The potential therapeutic significance of these findings is not yet known, but it seems possible that tumours with an intact receptor mechanism might benefit from oestrogen therapy and have a more favourable prognosis.
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spelling pubmed-20107332009-09-10 Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix. Soutter, W. P. Pegoraro, R. J. Green-Thompson, R. W. Naidoo, D. V. Joubert, S. M. Philpott, R. H. Br J Cancer Research Article Nuclear and cytoplasmic oestrogen receptors (REN and REC) were sought in 5 normal cervices and in 43 specimens of squamous carcinoma of the cervix. All 3 tissues components of the 5 normal cervices contained both REN and REC. Thirty-five (81%) of the tumours contained receptors, but in only 9 (21%) were they found in both subcellular compartments. Twenty-four tumours (56%) had only REC and 2 had only REN. The potential therapeutic significance of these findings is not yet known, but it seems possible that tumours with an intact receptor mechanism might benefit from oestrogen therapy and have a more favourable prognosis. Nature Publishing Group 1981-08 /pmc/articles/PMC2010733/ /pubmed/7272184 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Soutter, W. P.
Pegoraro, R. J.
Green-Thompson, R. W.
Naidoo, D. V.
Joubert, S. M.
Philpott, R. H.
Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.
title Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.
title_full Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.
title_fullStr Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.
title_full_unstemmed Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.
title_short Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.
title_sort nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010733/
https://www.ncbi.nlm.nih.gov/pubmed/7272184
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