Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.

Chinese hamster V79 cells cultured in vitro were used to investigated the cytotoxicity of various anti-cancer drugs subsequent to a prolonged treatment of the cells with Misonidazole (MISO). The sensitivity of the cells to Bleomycin (BLM), Melphalan or cis-Platinum (cis-DDP) was significantly increa...

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Autores principales: Roizin-Towle, L. A., Hall, E. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010744/
https://www.ncbi.nlm.nih.gov/pubmed/6168277
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author Roizin-Towle, L. A.
Hall, E. J.
author_facet Roizin-Towle, L. A.
Hall, E. J.
author_sort Roizin-Towle, L. A.
collection PubMed
description Chinese hamster V79 cells cultured in vitro were used to investigated the cytotoxicity of various anti-cancer drugs subsequent to a prolonged treatment of the cells with Misonidazole (MISO). The sensitivity of the cells to Bleomycin (BLM), Melphalan or cis-Platinum (cis-DDP) was significantly increased by prior incubation with MISO under hypoxic conditions. When cysteamine, a radical scavenger, was present during the pretreatment with MISO, this enhancement of cytotoxicity was greatly reduced. These experiments, suggest that MISO by virtue of its selective toxicity towards hypoxic cells and its enhancement of cell killing by anti-neoplastic drugs, can play an important role in cancer chemotherapy.
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spelling pubmed-20107442009-09-10 Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole. Roizin-Towle, L. A. Hall, E. J. Br J Cancer Research Article Chinese hamster V79 cells cultured in vitro were used to investigated the cytotoxicity of various anti-cancer drugs subsequent to a prolonged treatment of the cells with Misonidazole (MISO). The sensitivity of the cells to Bleomycin (BLM), Melphalan or cis-Platinum (cis-DDP) was significantly increased by prior incubation with MISO under hypoxic conditions. When cysteamine, a radical scavenger, was present during the pretreatment with MISO, this enhancement of cytotoxicity was greatly reduced. These experiments, suggest that MISO by virtue of its selective toxicity towards hypoxic cells and its enhancement of cell killing by anti-neoplastic drugs, can play an important role in cancer chemotherapy. Nature Publishing Group 1981-08 /pmc/articles/PMC2010744/ /pubmed/6168277 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Roizin-Towle, L. A.
Hall, E. J.
Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
title Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
title_full Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
title_fullStr Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
title_full_unstemmed Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
title_short Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
title_sort enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010744/
https://www.ncbi.nlm.nih.gov/pubmed/6168277
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