Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.

Cells from the established line NHIK 3025 were exposed to haematoporphyrin derivative and light. After this photodynamic treatment the first interphase of surviving cells was prolonged. Furthermore, a pronounced effect on the progression through the first mitosis was observed. Mainly the duration of...

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Autor principal: Christensen, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010756/
https://www.ncbi.nlm.nih.gov/pubmed/7197158
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author Christensen, T.
author_facet Christensen, T.
author_sort Christensen, T.
collection PubMed
description Cells from the established line NHIK 3025 were exposed to haematoporphyrin derivative and light. After this photodynamic treatment the first interphase of surviving cells was prolonged. Furthermore, a pronounced effect on the progression through the first mitosis was observed. Mainly the duration of metaphase was increased. Some of the cells were irreversibly arrested in mitosis and the cells that were able to complete mitosis after treatment multiplied in the subsequent generations at the same rate as the control. Cells treated in the late stages of the mitosis went out of mitosis at the same rate as the control. This indicates that the treatment with porphyrins and light induces a block in a specific stage of mitosis.
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spelling pubmed-20107562009-09-10 Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light. Christensen, T. Br J Cancer Research Article Cells from the established line NHIK 3025 were exposed to haematoporphyrin derivative and light. After this photodynamic treatment the first interphase of surviving cells was prolonged. Furthermore, a pronounced effect on the progression through the first mitosis was observed. Mainly the duration of metaphase was increased. Some of the cells were irreversibly arrested in mitosis and the cells that were able to complete mitosis after treatment multiplied in the subsequent generations at the same rate as the control. Cells treated in the late stages of the mitosis went out of mitosis at the same rate as the control. This indicates that the treatment with porphyrins and light induces a block in a specific stage of mitosis. Nature Publishing Group 1981-09 /pmc/articles/PMC2010756/ /pubmed/7197158 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Christensen, T.
Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.
title Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.
title_full Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.
title_fullStr Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.
title_full_unstemmed Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.
title_short Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.
title_sort multiplication of human nhik 3025 cells exposed to porphyrins in combination with light.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010756/
https://www.ncbi.nlm.nih.gov/pubmed/7197158
work_keys_str_mv AT christensent multiplicationofhumannhik3025cellsexposedtoporphyrinsincombinationwithlight

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