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Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice.
Two naturally occurring cytotoxic cell populations have been identified in the peritoneal cavity of mice inoculated with C. parvum (CP), and are distinguishable on the basis of target-cell reactivity and intrinsic properties. The first effector cell was non-adherent to nylon wool and glass and non-p...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1981
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010792/ https://www.ncbi.nlm.nih.gov/pubmed/7295509 |
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author | Hassan, Z. M. Rees, R. C. Potter, C. W. |
author_facet | Hassan, Z. M. Rees, R. C. Potter, C. W. |
author_sort | Hassan, Z. M. |
collection | PubMed |
description | Two naturally occurring cytotoxic cell populations have been identified in the peritoneal cavity of mice inoculated with C. parvum (CP), and are distinguishable on the basis of target-cell reactivity and intrinsic properties. The first effector cell was non-adherent to nylon wool and glass and non-phagocytic. These cells were selectively cytotoxic to the NK-sensitive target cell line K562, and present in the peritoneal cavity of mice 2 days after treatment with 700 micrograms of CP. The second cytotoxic effector cell was adherent to nylon wool and glass, and killed EL4 lymphoma cells derived from in vivo tumour transplants; these target cells are susceptible to phagocytic cell killing, but not NK-cell cytotoxicity in short-term (4h) assays. The adherent cytotoxic population of effector cells was present 4 days after inoculation of CP. In vivo studies showed that CP injected i.p. induced resistance to i.p. challenge with lymphoma EL4 cells, but no resistance was evident when the challenge dose was administered s.c. Adoptive-transfer studies showed that the effector cell type responsible for inhibiting tumour growth was nylon-wool adherent, probably CP-activated macrophages. |
format | Text |
id | pubmed-2010792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20107922009-09-10 Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. Hassan, Z. M. Rees, R. C. Potter, C. W. Br J Cancer Research Article Two naturally occurring cytotoxic cell populations have been identified in the peritoneal cavity of mice inoculated with C. parvum (CP), and are distinguishable on the basis of target-cell reactivity and intrinsic properties. The first effector cell was non-adherent to nylon wool and glass and non-phagocytic. These cells were selectively cytotoxic to the NK-sensitive target cell line K562, and present in the peritoneal cavity of mice 2 days after treatment with 700 micrograms of CP. The second cytotoxic effector cell was adherent to nylon wool and glass, and killed EL4 lymphoma cells derived from in vivo tumour transplants; these target cells are susceptible to phagocytic cell killing, but not NK-cell cytotoxicity in short-term (4h) assays. The adherent cytotoxic population of effector cells was present 4 days after inoculation of CP. In vivo studies showed that CP injected i.p. induced resistance to i.p. challenge with lymphoma EL4 cells, but no resistance was evident when the challenge dose was administered s.c. Adoptive-transfer studies showed that the effector cell type responsible for inhibiting tumour growth was nylon-wool adherent, probably CP-activated macrophages. Nature Publishing Group 1981-10 /pmc/articles/PMC2010792/ /pubmed/7295509 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Hassan, Z. M. Rees, R. C. Potter, C. W. Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. |
title | Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. |
title_full | Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. |
title_fullStr | Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. |
title_full_unstemmed | Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. |
title_short | Corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. |
title_sort | corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010792/ https://www.ncbi.nlm.nih.gov/pubmed/7295509 |
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