Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.

An analysis of survival time of 57 West European patients with hepatocellular carcinoma was carried out to define which of several possible factors (age, sex, cirrhosis and raised serum alpha-foetoprotein (AFP)) influenced survival. Although survival was significantly longer in younger patients (P l...

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Autores principales: Johnson, P. J., Melia, W. M., Palmer, M. K., Portmann, B., Williams, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010797/
https://www.ncbi.nlm.nih.gov/pubmed/6170301
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author Johnson, P. J.
Melia, W. M.
Palmer, M. K.
Portmann, B.
Williams, R.
author_facet Johnson, P. J.
Melia, W. M.
Palmer, M. K.
Portmann, B.
Williams, R.
author_sort Johnson, P. J.
collection PubMed
description An analysis of survival time of 57 West European patients with hepatocellular carcinoma was carried out to define which of several possible factors (age, sex, cirrhosis and raised serum alpha-foetoprotein (AFP)) influenced survival. Although survival was significantly longer in younger patients (P less than 0.02) and in patients with normal serum AFP (P less than 0.01), multivariate analysis showed that significant variation in survival time is better explained by the single factor, the presence of cirrhosis, than by AFP level. This does not seem to apply for patients with this tumour in Africa and the Far East, and there may be a fundamental difference in the natural history of the tumour between high- and low-incidence areas.
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spelling pubmed-20107972009-09-10 Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma. Johnson, P. J. Melia, W. M. Palmer, M. K. Portmann, B. Williams, R. Br J Cancer Research Article An analysis of survival time of 57 West European patients with hepatocellular carcinoma was carried out to define which of several possible factors (age, sex, cirrhosis and raised serum alpha-foetoprotein (AFP)) influenced survival. Although survival was significantly longer in younger patients (P less than 0.02) and in patients with normal serum AFP (P less than 0.01), multivariate analysis showed that significant variation in survival time is better explained by the single factor, the presence of cirrhosis, than by AFP level. This does not seem to apply for patients with this tumour in Africa and the Far East, and there may be a fundamental difference in the natural history of the tumour between high- and low-incidence areas. Nature Publishing Group 1981-10 /pmc/articles/PMC2010797/ /pubmed/6170301 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Johnson, P. J.
Melia, W. M.
Palmer, M. K.
Portmann, B.
Williams, R.
Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
title Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
title_full Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
title_fullStr Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
title_full_unstemmed Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
title_short Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
title_sort relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010797/
https://www.ncbi.nlm.nih.gov/pubmed/6170301
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