Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.

Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice. Administration of ND did not affect the anti-tumour action of CCNU against a transplantable mouse adenocarcinoma of the co...

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Detalles Bibliográficos
Autores principales: Bibby, M. C., Double, J. A., Mughal, M. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010805/
https://www.ncbi.nlm.nih.gov/pubmed/7295514
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author Bibby, M. C.
Double, J. A.
Mughal, M. A.
author_facet Bibby, M. C.
Double, J. A.
Mughal, M. A.
author_sort Bibby, M. C.
collection PubMed
description Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice. Administration of ND did not affect the anti-tumour action of CCNU against a transplantable mouse adenocarcinoma of the colon (MAC 13) or the anti-tumour action of FU against MAC 26. In both tumour lines ND had no significant effect on tumour growth. These data suggest that an increase in the anti-tumour selectivity of these agents may be produced by pre-treatment with ND.
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spelling pubmed-20108052009-09-10 Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours. Bibby, M. C. Double, J. A. Mughal, M. A. Br J Cancer Research Article Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice. Administration of ND did not affect the anti-tumour action of CCNU against a transplantable mouse adenocarcinoma of the colon (MAC 13) or the anti-tumour action of FU against MAC 26. In both tumour lines ND had no significant effect on tumour growth. These data suggest that an increase in the anti-tumour selectivity of these agents may be produced by pre-treatment with ND. Nature Publishing Group 1981-10 /pmc/articles/PMC2010805/ /pubmed/7295514 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bibby, M. C.
Double, J. A.
Mughal, M. A.
Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
title Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
title_full Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
title_fullStr Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
title_full_unstemmed Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
title_short Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
title_sort effects of nandrolone decanoate on the toxicity and anti-tumour action of ccnu and fu in murine tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010805/
https://www.ncbi.nlm.nih.gov/pubmed/7295514
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