Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.

The antitumour effects of ICRF-159 and related analogues were evaluated using the B16 melanoma. Treatment of mice with ICRF-159 inhibited tumour growth, while each of the analogues, trans-4,4(1)-(1,2-cyclopropandiyl) bis (2,6-piperazinedione) (trans-5), and cis-4,4(1)-(1,2-cyclopropandiyl) bis (2,6-...

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Autores principales: Zwilling, B. S., Campolito, L. B., Reiches, N. A., George, T., Witiak, D. T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010813/
https://www.ncbi.nlm.nih.gov/pubmed/7295515
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author Zwilling, B. S.
Campolito, L. B.
Reiches, N. A.
George, T.
Witiak, D. T.
author_facet Zwilling, B. S.
Campolito, L. B.
Reiches, N. A.
George, T.
Witiak, D. T.
author_sort Zwilling, B. S.
collection PubMed
description The antitumour effects of ICRF-159 and related analogues were evaluated using the B16 melanoma. Treatment of mice with ICRF-159 inhibited tumour growth, while each of the analogues, trans-4,4(1)-(1,2-cyclopropandiyl) bis (2,6-piperazinedione) (trans-5), and cis-4,4(1)-(1,2-cyclopropandiyl) bis (2,6-piperazinedione) (cis-7) independently accelerated primary tumour growth. Pretreatment of B16 melanoma cultures either with ICRF-159 or the analogue cis-7 decreased the yield of lung-colonies following i.v. injection of tumour cells. In contrast, pretreatment of tumour cells with the trans-5 analogue led to an increase in lung colonies. The effect on colony formation in vitro of these analogues correlated with increased growth in vivo, and not with lung colony formation.
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spelling pubmed-20108132009-09-10 Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma. Zwilling, B. S. Campolito, L. B. Reiches, N. A. George, T. Witiak, D. T. Br J Cancer Research Article The antitumour effects of ICRF-159 and related analogues were evaluated using the B16 melanoma. Treatment of mice with ICRF-159 inhibited tumour growth, while each of the analogues, trans-4,4(1)-(1,2-cyclopropandiyl) bis (2,6-piperazinedione) (trans-5), and cis-4,4(1)-(1,2-cyclopropandiyl) bis (2,6-piperazinedione) (cis-7) independently accelerated primary tumour growth. Pretreatment of B16 melanoma cultures either with ICRF-159 or the analogue cis-7 decreased the yield of lung-colonies following i.v. injection of tumour cells. In contrast, pretreatment of tumour cells with the trans-5 analogue led to an increase in lung colonies. The effect on colony formation in vitro of these analogues correlated with increased growth in vivo, and not with lung colony formation. Nature Publishing Group 1981-10 /pmc/articles/PMC2010813/ /pubmed/7295515 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Zwilling, B. S.
Campolito, L. B.
Reiches, N. A.
George, T.
Witiak, D. T.
Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.
title Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.
title_full Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.
title_fullStr Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.
title_full_unstemmed Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.
title_short Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.
title_sort effect of stereoisomers related to icrf-159 on metastasis of b16 melanoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010813/
https://www.ncbi.nlm.nih.gov/pubmed/7295515
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