Cellular distribution of monoclonal antibody in human tumours after i.v. administration.

Immune-suppressed mice carrying xenografts of several different types of human germ-cell tumours were injected with a radiolabelled monoclonal antibody (LICR LON/HT13) raised against membrane components of a human germ-cell tumour (HX39). Subsequent assessment of radioactivity in excised organs and...

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Autores principales: Moshakis, V., McIlhinney, R. A., Neville, A. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010824/
https://www.ncbi.nlm.nih.gov/pubmed/6172141
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author Moshakis, V.
McIlhinney, R. A.
Neville, A. M.
author_facet Moshakis, V.
McIlhinney, R. A.
Neville, A. M.
author_sort Moshakis, V.
collection PubMed
description Immune-suppressed mice carrying xenografts of several different types of human germ-cell tumours were injected with a radiolabelled monoclonal antibody (LICR LON/HT13) raised against membrane components of a human germ-cell tumour (HX39). Subsequent assessment of radioactivity in excised organs and tumours showed a selective accretion of antibody in the tumour. Quantitative autoradiography supported the results of radiolocalization observed in vivo in different tumours, and also showed that the antibody localized to viable tumour cells and in close association with their cell membrane. The vascular architecture of tumours was found to be an important factor governing antibody distribution. No localization occurred with radiolabelled normal mouse IgG. IMAGES:
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spelling pubmed-20108242009-09-10 Cellular distribution of monoclonal antibody in human tumours after i.v. administration. Moshakis, V. McIlhinney, R. A. Neville, A. M. Br J Cancer Research Article Immune-suppressed mice carrying xenografts of several different types of human germ-cell tumours were injected with a radiolabelled monoclonal antibody (LICR LON/HT13) raised against membrane components of a human germ-cell tumour (HX39). Subsequent assessment of radioactivity in excised organs and tumours showed a selective accretion of antibody in the tumour. Quantitative autoradiography supported the results of radiolocalization observed in vivo in different tumours, and also showed that the antibody localized to viable tumour cells and in close association with their cell membrane. The vascular architecture of tumours was found to be an important factor governing antibody distribution. No localization occurred with radiolabelled normal mouse IgG. IMAGES: Nature Publishing Group 1981-11 /pmc/articles/PMC2010824/ /pubmed/6172141 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Moshakis, V.
McIlhinney, R. A.
Neville, A. M.
Cellular distribution of monoclonal antibody in human tumours after i.v. administration.
title Cellular distribution of monoclonal antibody in human tumours after i.v. administration.
title_full Cellular distribution of monoclonal antibody in human tumours after i.v. administration.
title_fullStr Cellular distribution of monoclonal antibody in human tumours after i.v. administration.
title_full_unstemmed Cellular distribution of monoclonal antibody in human tumours after i.v. administration.
title_short Cellular distribution of monoclonal antibody in human tumours after i.v. administration.
title_sort cellular distribution of monoclonal antibody in human tumours after i.v. administration.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010824/
https://www.ncbi.nlm.nih.gov/pubmed/6172141
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AT nevilleam cellulardistributionofmonoclonalantibodyinhumantumoursafterivadministration

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