Folate catabolism in tumour-bearing rats and rats treated with methotrexate.

The metabolism of (2-14C) + (3',5',7,9-3H) folic acid was studied in normal rats, tumour-bearing rats and rats treated with methotrexate (MTX). The experiments were designed to investigate changes in the catabolism and folate. The breakdown of folate to scission products was again demonstr...

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Detalles Bibliográficos
Autores principales: Saleh, A. M., Pheasant, A. E., Blair, J. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010830/
https://www.ncbi.nlm.nih.gov/pubmed/6976181
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author Saleh, A. M.
Pheasant, A. E.
Blair, J. A.
author_facet Saleh, A. M.
Pheasant, A. E.
Blair, J. A.
author_sort Saleh, A. M.
collection PubMed
description The metabolism of (2-14C) + (3',5',7,9-3H) folic acid was studied in normal rats, tumour-bearing rats and rats treated with methotrexate (MTX). The experiments were designed to investigate changes in the catabolism and folate. The breakdown of folate to scission products was again demonstrated to be a normal phenomenon. Catabolites excreted included p-acetamidobenzoate, p-acetamidobenzoyl-L-glutamate, 3H2O, urea and a number of pterins. The catabolic process was decreased in the presence of a tumour and increased by the administration of MTX. MTX also led to the excretion of 4 additional radioactive pterins not found in normal urine. The possible mechanisms of folate breakdown are discussed with reference to the point of action of MTX.
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spelling pubmed-20108302009-09-10 Folate catabolism in tumour-bearing rats and rats treated with methotrexate. Saleh, A. M. Pheasant, A. E. Blair, J. A. Br J Cancer Research Article The metabolism of (2-14C) + (3',5',7,9-3H) folic acid was studied in normal rats, tumour-bearing rats and rats treated with methotrexate (MTX). The experiments were designed to investigate changes in the catabolism and folate. The breakdown of folate to scission products was again demonstrated to be a normal phenomenon. Catabolites excreted included p-acetamidobenzoate, p-acetamidobenzoyl-L-glutamate, 3H2O, urea and a number of pterins. The catabolic process was decreased in the presence of a tumour and increased by the administration of MTX. MTX also led to the excretion of 4 additional radioactive pterins not found in normal urine. The possible mechanisms of folate breakdown are discussed with reference to the point of action of MTX. Nature Publishing Group 1981-11 /pmc/articles/PMC2010830/ /pubmed/6976181 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Saleh, A. M.
Pheasant, A. E.
Blair, J. A.
Folate catabolism in tumour-bearing rats and rats treated with methotrexate.
title Folate catabolism in tumour-bearing rats and rats treated with methotrexate.
title_full Folate catabolism in tumour-bearing rats and rats treated with methotrexate.
title_fullStr Folate catabolism in tumour-bearing rats and rats treated with methotrexate.
title_full_unstemmed Folate catabolism in tumour-bearing rats and rats treated with methotrexate.
title_short Folate catabolism in tumour-bearing rats and rats treated with methotrexate.
title_sort folate catabolism in tumour-bearing rats and rats treated with methotrexate.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010830/
https://www.ncbi.nlm.nih.gov/pubmed/6976181
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AT pheasantae folatecatabolismintumourbearingratsandratstreatedwithmethotrexate
AT blairja folatecatabolismintumourbearingratsandratstreatedwithmethotrexate

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