Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.

The primary reaction of the macrophage electrophoretic mobility test (MEM) and its modifications (viz. the interaction of myelin basic protein (MBP) and mononuclear cells) has been investigated. The binding of MBP to mononuclear cells is rather weak, and on incubation with mononuclear cells the MBP...

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Detalles Bibliográficos
Autores principales: Goppelt, M., Grol, M., Pingoud, A., Schumacher, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010855/
https://www.ncbi.nlm.nih.gov/pubmed/6173054
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author Goppelt, M.
Grol, M.
Pingoud, A.
Schumacher, K.
author_facet Goppelt, M.
Grol, M.
Pingoud, A.
Schumacher, K.
author_sort Goppelt, M.
collection PubMed
description The primary reaction of the macrophage electrophoretic mobility test (MEM) and its modifications (viz. the interaction of myelin basic protein (MBP) and mononuclear cells) has been investigated. The binding of MBP to mononuclear cells is rather weak, and on incubation with mononuclear cells the MBP is proteolytically degraded. A fast process leads to fragments with mol. wts in the range 9000-14,000, followed by a slower process leading to peptides smaller than 5000. Both binding and proteolytic degradation are the same for mononuclear cells from cancer patients and from control individuals.
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spelling pubmed-20108552009-09-10 Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests. Goppelt, M. Grol, M. Pingoud, A. Schumacher, K. Br J Cancer Research Article The primary reaction of the macrophage electrophoretic mobility test (MEM) and its modifications (viz. the interaction of myelin basic protein (MBP) and mononuclear cells) has been investigated. The binding of MBP to mononuclear cells is rather weak, and on incubation with mononuclear cells the MBP is proteolytically degraded. A fast process leads to fragments with mol. wts in the range 9000-14,000, followed by a slower process leading to peptides smaller than 5000. Both binding and proteolytic degradation are the same for mononuclear cells from cancer patients and from control individuals. Nature Publishing Group 1981-12 /pmc/articles/PMC2010855/ /pubmed/6173054 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Goppelt, M.
Grol, M.
Pingoud, A.
Schumacher, K.
Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.
title Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.
title_full Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.
title_fullStr Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.
title_full_unstemmed Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.
title_short Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.
title_sort interaction of myelin basic protein with mononuclear cells: the primary reaction for the mem and emt tests.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010855/
https://www.ncbi.nlm.nih.gov/pubmed/6173054
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AT pingouda interactionofmyelinbasicproteinwithmononuclearcellstheprimaryreactionforthememandemttests
AT schumacherk interactionofmyelinbasicproteinwithmononuclearcellstheprimaryreactionforthememandemttests

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