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Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.

Groups of male and female beagle dogs were given daily doses of 400 mg of various mixtures of naphthylamines for up to 109 months. Survivors were killed at 128 months. A variety of pathological conditions was diagnosed, but the only effect related to treatment was the induction of bladder neoplasms....

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Autores principales: Purchase, I. F., Kalinowski, A. E., Ishmael, J., Wilson, J., Gore, C. W., Chart, I. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010866/
https://www.ncbi.nlm.nih.gov/pubmed/7326199
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author Purchase, I. F.
Kalinowski, A. E.
Ishmael, J.
Wilson, J.
Gore, C. W.
Chart, I. S.
author_facet Purchase, I. F.
Kalinowski, A. E.
Ishmael, J.
Wilson, J.
Gore, C. W.
Chart, I. S.
author_sort Purchase, I. F.
collection PubMed
description Groups of male and female beagle dogs were given daily doses of 400 mg of various mixtures of naphthylamines for up to 109 months. Survivors were killed at 128 months. A variety of pathological conditions was diagnosed, but the only effect related to treatment was the induction of bladder neoplasms. All dogs which received pure 2-naphthylamine developed transitional-cell carcinomas of the bladder within 34 months. Two of 8 dogs receiving 6% 2-naphthylamine in 1-naphthylamine developed early carcinoma and 2/8 dogs receiving 0.5% 2-naphthylamine in 1-naphthylamine developed haemangioma of the bladder. Some of the dogs receiving 1-naphthylamine (total dose 950 g) and the controls had focal cystitis or hyperplasia, but no neoplasia of the bladder. These results confirm the carcinogenicity of 2-naphthylamine to dogs. No carcinogenic effect of 1-naphthylamine was observed, indicating that it is at least 200 times less potent as a carcinogen than 2-naphthylamine. The incidence of bladder cancer in dogs fed mixtures of both naphthylamines explains why previous experimental and epidemiological studies of impure 1-naphthylamine have revealed carcinogenicity. IMAGES:
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spelling pubmed-20108662009-09-10 Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs. Purchase, I. F. Kalinowski, A. E. Ishmael, J. Wilson, J. Gore, C. W. Chart, I. S. Br J Cancer Research Article Groups of male and female beagle dogs were given daily doses of 400 mg of various mixtures of naphthylamines for up to 109 months. Survivors were killed at 128 months. A variety of pathological conditions was diagnosed, but the only effect related to treatment was the induction of bladder neoplasms. All dogs which received pure 2-naphthylamine developed transitional-cell carcinomas of the bladder within 34 months. Two of 8 dogs receiving 6% 2-naphthylamine in 1-naphthylamine developed early carcinoma and 2/8 dogs receiving 0.5% 2-naphthylamine in 1-naphthylamine developed haemangioma of the bladder. Some of the dogs receiving 1-naphthylamine (total dose 950 g) and the controls had focal cystitis or hyperplasia, but no neoplasia of the bladder. These results confirm the carcinogenicity of 2-naphthylamine to dogs. No carcinogenic effect of 1-naphthylamine was observed, indicating that it is at least 200 times less potent as a carcinogen than 2-naphthylamine. The incidence of bladder cancer in dogs fed mixtures of both naphthylamines explains why previous experimental and epidemiological studies of impure 1-naphthylamine have revealed carcinogenicity. IMAGES: Nature Publishing Group 1981-12 /pmc/articles/PMC2010866/ /pubmed/7326199 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Purchase, I. F.
Kalinowski, A. E.
Ishmael, J.
Wilson, J.
Gore, C. W.
Chart, I. S.
Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.
title Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.
title_full Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.
title_fullStr Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.
title_full_unstemmed Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.
title_short Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.
title_sort lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010866/
https://www.ncbi.nlm.nih.gov/pubmed/7326199
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