Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.

Experiments were conducted to determine whether the histological pattern of tumour growth of hormone-responsive MCF-7 human mammary adenocarcinoma varied in different tissues of athymic mice. Tumours in the uterus following intrauterine injection were rapidly proliferating and highly invasive. Tumou...

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Autores principales: Levy, J. A., White, A. C., McGrath, C. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010919/
https://www.ncbi.nlm.nih.gov/pubmed/7073933
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author Levy, J. A.
White, A. C.
McGrath, C. M.
author_facet Levy, J. A.
White, A. C.
McGrath, C. M.
author_sort Levy, J. A.
collection PubMed
description Experiments were conducted to determine whether the histological pattern of tumour growth of hormone-responsive MCF-7 human mammary adenocarcinoma varied in different tissues of athymic mice. Tumours in the uterus following intrauterine injection were rapidly proliferating and highly invasive. Tumours injected intracerebrally were also highly invasive. In contrast, s.c. tumours and those which arose in the lung following intrapleural injection, grew as small localized nodules without evidence of aggressive invasion of surrounding tissues. These findings indicate that selective implantation of human tumours in athymic mice can be used to develop different models of tumour growth and aggressiveness. IMAGES:
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spelling pubmed-20109192009-09-10 Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse. Levy, J. A. White, A. C. McGrath, C. M. Br J Cancer Research Article Experiments were conducted to determine whether the histological pattern of tumour growth of hormone-responsive MCF-7 human mammary adenocarcinoma varied in different tissues of athymic mice. Tumours in the uterus following intrauterine injection were rapidly proliferating and highly invasive. Tumours injected intracerebrally were also highly invasive. In contrast, s.c. tumours and those which arose in the lung following intrapleural injection, grew as small localized nodules without evidence of aggressive invasion of surrounding tissues. These findings indicate that selective implantation of human tumours in athymic mice can be used to develop different models of tumour growth and aggressiveness. IMAGES: Nature Publishing Group 1982-03 /pmc/articles/PMC2010919/ /pubmed/7073933 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Levy, J. A.
White, A. C.
McGrath, C. M.
Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.
title Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.
title_full Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.
title_fullStr Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.
title_full_unstemmed Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.
title_short Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.
title_sort growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010919/
https://www.ncbi.nlm.nih.gov/pubmed/7073933
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