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Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment.
Mesothelioma death rates in asbestos workers appear to be proportional to the 3rd or 4th power of time from first exposure under a wide range of conditions of exposure for both pleural and peritoneal tumours, though the peritoneal:pleural ratio depends on fibre dimension and type. Age at first expos...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1982
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010947/ https://www.ncbi.nlm.nih.gov/pubmed/7059455 |
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author | Peto, J. Seidman, H. Selikoff, I. J. |
author_facet | Peto, J. Seidman, H. Selikoff, I. J. |
author_sort | Peto, J. |
collection | PubMed |
description | Mesothelioma death rates in asbestos workers appear to be proportional to the 3rd or 4th power of time from first exposure under a wide range of conditions of exposure for both pleural and peritoneal tumours, though the peritoneal:pleural ratio depends on fibre dimension and type. Age at first exposure has little or no influence, however, which supports the "multi-stage" model of carcinogenesis under which the increase in most cancer incidence rates with age is due to a constant incidence of genetic or epigenetic accidents, rather than to progressive generalized changes in regulatory or immune function. These relationships provide a simple basis for risk assessment, and support the suggestion that mesotheliomas may constitute a high proportion of cancer deaths resulting from early exposure to asbestos. |
format | Text |
id | pubmed-2010947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1982 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20109472009-09-10 Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. Peto, J. Seidman, H. Selikoff, I. J. Br J Cancer Research Article Mesothelioma death rates in asbestos workers appear to be proportional to the 3rd or 4th power of time from first exposure under a wide range of conditions of exposure for both pleural and peritoneal tumours, though the peritoneal:pleural ratio depends on fibre dimension and type. Age at first exposure has little or no influence, however, which supports the "multi-stage" model of carcinogenesis under which the increase in most cancer incidence rates with age is due to a constant incidence of genetic or epigenetic accidents, rather than to progressive generalized changes in regulatory or immune function. These relationships provide a simple basis for risk assessment, and support the suggestion that mesotheliomas may constitute a high proportion of cancer deaths resulting from early exposure to asbestos. Nature Publishing Group 1982-01 /pmc/articles/PMC2010947/ /pubmed/7059455 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Peto, J. Seidman, H. Selikoff, I. J. Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. |
title | Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. |
title_full | Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. |
title_fullStr | Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. |
title_full_unstemmed | Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. |
title_short | Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. |
title_sort | mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010947/ https://www.ncbi.nlm.nih.gov/pubmed/7059455 |
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