Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.

N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams, J. C., Gusterson, B. A., Coombes, R. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010985/
https://www.ncbi.nlm.nih.gov/pubmed/7073949
_version_ 1782136436674265088
author Williams, J. C.
Gusterson, B. A.
Coombes, R. C.
author_facet Williams, J. C.
Gusterson, B. A.
Coombes, R. C.
author_sort Williams, J. C.
collection PubMed
description N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis. IMAGES:
format Text
id pubmed-2010985
institution National Center for Biotechnology Information
language English
publishDate 1982
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20109852009-09-10 Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour. Williams, J. C. Gusterson, B. A. Coombes, R. C. Br J Cancer Research Article N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis. IMAGES: Nature Publishing Group 1982-04 /pmc/articles/PMC2010985/ /pubmed/7073949 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Williams, J. C.
Gusterson, B. A.
Coombes, R. C.
Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
title Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
title_full Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
title_fullStr Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
title_full_unstemmed Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
title_short Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
title_sort spontaneously metastasizing variants derived from mnu-induced rat mammary tumour.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010985/
https://www.ncbi.nlm.nih.gov/pubmed/7073949
work_keys_str_mv AT williamsjc spontaneouslymetastasizingvariantsderivedfrommnuinducedratmammarytumour
AT gustersonba spontaneouslymetastasizingvariantsderivedfrommnuinducedratmammarytumour
AT coombesrc spontaneouslymetastasizingvariantsderivedfrommnuinducedratmammarytumour

Ejemplares similares