Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.

A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of mice bearing the PC6 myeloma in the dose range 2-7 mg/kg. However, these doses were toxic, and the LD50 was 6-7 mg/kg. When incorporated in li...

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Detalles Bibliográficos
Autores principales: Babbage, J. W., Berenbaum, M. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011043/
https://www.ncbi.nlm.nih.gov/pubmed/7093119
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author Babbage, J. W.
Berenbaum, M. C.
author_facet Babbage, J. W.
Berenbaum, M. C.
author_sort Babbage, J. W.
collection PubMed
description A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of mice bearing the PC6 myeloma in the dose range 2-7 mg/kg. However, these doses were toxic, and the LD50 was 6-7 mg/kg. When incorporated in liposomes, similar curative effects were obtained at doses of 10-41 mg/kg without material toxicity, even at the highest dose. Liposome entrapment therefore greatly increases the therapeutic efficiency of this agent.
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spelling pubmed-20110432009-09-10 Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes. Babbage, J. W. Berenbaum, M. C. Br J Cancer Research Article A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of mice bearing the PC6 myeloma in the dose range 2-7 mg/kg. However, these doses were toxic, and the LD50 was 6-7 mg/kg. When incorporated in liposomes, similar curative effects were obtained at doses of 10-41 mg/kg without material toxicity, even at the highest dose. Liposome entrapment therefore greatly increases the therapeutic efficiency of this agent. Nature Publishing Group 1982-06 /pmc/articles/PMC2011043/ /pubmed/7093119 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Babbage, J. W.
Berenbaum, M. C.
Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.
title Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.
title_full Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.
title_fullStr Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.
title_full_unstemmed Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.
title_short Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.
title_sort increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011043/
https://www.ncbi.nlm.nih.gov/pubmed/7093119
work_keys_str_mv AT babbagejw increasedtherapeuticefficiencyofalipidsolublealkylatingagentincorporatedinliposomes
AT berenbaummc increasedtherapeuticefficiencyofalipidsolublealkylatingagentincorporatedinliposomes

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