Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.

Enhancement of CCNU cytotoxicity by misonidazole (MISO) was studied in three tumours and two normal tissues in the mouse. The 3 experimental tumours (SCCVII/St, EMT6 and KHT) showed very different sensitivities to CCNU alone, but MISO enhanced the cell killing in ech case. The effect was not always...

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Autores principales: Hirst, D. G., Brown, J. M., Hazlehurst, J. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011076/
https://www.ncbi.nlm.nih.gov/pubmed/7201845
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author Hirst, D. G.
Brown, J. M.
Hazlehurst, J. L.
author_facet Hirst, D. G.
Brown, J. M.
Hazlehurst, J. L.
author_sort Hirst, D. G.
collection PubMed
description Enhancement of CCNU cytotoxicity by misonidazole (MISO) was studied in three tumours and two normal tissues in the mouse. The 3 experimental tumours (SCCVII/St, EMT6 and KHT) showed very different sensitivities to CCNU alone, but MISO enhanced the cell killing in ech case. The effect was not always dose-modifying, so that the CCNU dose range for the greatest enhancement was different in each of the tumours. In all 3 tumours, enhancement increased with dose of MISO. The effect on two normal tissues, marrow (CFU-S) and testis (spermatogonia), was also investigated. Enhancement of marrow toxicity could be demonstrated only at CCNU doses greater than 12.5 mg/kg, so that at lower CCNU doses there was a therapeutic gain equal to the tumour enhancement ratio. The spermatogonia effect, however, showed enhancement by MISO similar to that seen in the tumours at all CCNU doses up to 20 mg/kg.
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spelling pubmed-20110762009-09-10 Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain. Hirst, D. G. Brown, J. M. Hazlehurst, J. L. Br J Cancer Research Article Enhancement of CCNU cytotoxicity by misonidazole (MISO) was studied in three tumours and two normal tissues in the mouse. The 3 experimental tumours (SCCVII/St, EMT6 and KHT) showed very different sensitivities to CCNU alone, but MISO enhanced the cell killing in ech case. The effect was not always dose-modifying, so that the CCNU dose range for the greatest enhancement was different in each of the tumours. In all 3 tumours, enhancement increased with dose of MISO. The effect on two normal tissues, marrow (CFU-S) and testis (spermatogonia), was also investigated. Enhancement of marrow toxicity could be demonstrated only at CCNU doses greater than 12.5 mg/kg, so that at lower CCNU doses there was a therapeutic gain equal to the tumour enhancement ratio. The spermatogonia effect, however, showed enhancement by MISO similar to that seen in the tumours at all CCNU doses up to 20 mg/kg. Nature Publishing Group 1982-07 /pmc/articles/PMC2011076/ /pubmed/7201845 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hirst, D. G.
Brown, J. M.
Hazlehurst, J. L.
Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
title Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
title_full Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
title_fullStr Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
title_full_unstemmed Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
title_short Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
title_sort enhancement of ccnu cytotoxicity by misonidazole: possible therapeutic gain.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011076/
https://www.ncbi.nlm.nih.gov/pubmed/7201845
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