Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.

Serum sialyl transferase (SST) was measured in 49 female patients with advanced breast cancer and 60 female controls. The mean SST level was significantly raised in patients with advanced breast cancer. There was no correlation between specific sites, or numbers of sites of metastatic disease and SS...

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Detalles Bibliográficos
Autores principales: Stewart, J. F., Rubens, R. D., Hoare, S., Bulbrook, R. D., Kessel, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011080/
https://www.ncbi.nlm.nih.gov/pubmed/6758827
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author Stewart, J. F.
Rubens, R. D.
Hoare, S.
Bulbrook, R. D.
Kessel, D.
author_facet Stewart, J. F.
Rubens, R. D.
Hoare, S.
Bulbrook, R. D.
Kessel, D.
author_sort Stewart, J. F.
collection PubMed
description Serum sialyl transferase (SST) was measured in 49 female patients with advanced breast cancer and 60 female controls. The mean SST level was significantly raised in patients with advanced breast cancer. There was no correlation between specific sites, or numbers of sites of metastatic disease and SST levels. The patients with advanced breast cancer were all treated with chemotherapy; in 13/21 responders there was a significant fall in SST and in 2 responders a significant rise in SST. The 6 patients who died after one course of chemotherapy had a significantly higher mean SST than those surviving longer. SST appears to lack sufficient specificity to be of practical value as a marker of response in patients with breast cancer treated by chemotherapy, though constant measurement of changes in SST may be of use in monitoring drug response. Raised SST at the commencement of chemotherapy may signify poor prognosis.
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spelling pubmed-20110802009-09-10 Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy. Stewart, J. F. Rubens, R. D. Hoare, S. Bulbrook, R. D. Kessel, D. Br J Cancer Research Article Serum sialyl transferase (SST) was measured in 49 female patients with advanced breast cancer and 60 female controls. The mean SST level was significantly raised in patients with advanced breast cancer. There was no correlation between specific sites, or numbers of sites of metastatic disease and SST levels. The patients with advanced breast cancer were all treated with chemotherapy; in 13/21 responders there was a significant fall in SST and in 2 responders a significant rise in SST. The 6 patients who died after one course of chemotherapy had a significantly higher mean SST than those surviving longer. SST appears to lack sufficient specificity to be of practical value as a marker of response in patients with breast cancer treated by chemotherapy, though constant measurement of changes in SST may be of use in monitoring drug response. Raised SST at the commencement of chemotherapy may signify poor prognosis. Nature Publishing Group 1982-08 /pmc/articles/PMC2011080/ /pubmed/6758827 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Stewart, J. F.
Rubens, R. D.
Hoare, S.
Bulbrook, R. D.
Kessel, D.
Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.
title Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.
title_full Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.
title_fullStr Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.
title_full_unstemmed Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.
title_short Serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.
title_sort serum sialyl transferase levels in patients with metastatic breast cancer treated by chemotherapy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011080/
https://www.ncbi.nlm.nih.gov/pubmed/6758827
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