Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.

We report evidence for the secretion of a true mammalian collagenase active against Type 1 collagen, by naturally-occurring mammary tumours of the mouse and show that tumours capable of heavily colonizing the lungs secrete significantly more of this enzyme than those with low pulmonary-colonization...

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Detalles Bibliográficos
Autores principales: Tarin, D., Hoyt, B. J., Evans, D. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011086/
https://www.ncbi.nlm.nih.gov/pubmed/6295423
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author Tarin, D.
Hoyt, B. J.
Evans, D. J.
author_facet Tarin, D.
Hoyt, B. J.
Evans, D. J.
author_sort Tarin, D.
collection PubMed
description We report evidence for the secretion of a true mammalian collagenase active against Type 1 collagen, by naturally-occurring mammary tumours of the mouse and show that tumours capable of heavily colonizing the lungs secrete significantly more of this enzyme than those with low pulmonary-colonization potential, or non-neoplastic proliferating (e.g. lactating) mammary tissue. Plasminogen activator is secreted in greater quantity by tumours than by normal tissues, but there is no significant difference in the amount produced by tumours with high or low pulmonary-colonization potential. These findings correlate well with our earlier morphological observations of marked connective tissue destruction in the vicinity of invading tumours and metastatic deposits, and indicate that protease release is implicated in the mechanism of tumour spread. IMAGES:
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spelling pubmed-20110862009-09-10 Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours. Tarin, D. Hoyt, B. J. Evans, D. J. Br J Cancer Research Article We report evidence for the secretion of a true mammalian collagenase active against Type 1 collagen, by naturally-occurring mammary tumours of the mouse and show that tumours capable of heavily colonizing the lungs secrete significantly more of this enzyme than those with low pulmonary-colonization potential, or non-neoplastic proliferating (e.g. lactating) mammary tissue. Plasminogen activator is secreted in greater quantity by tumours than by normal tissues, but there is no significant difference in the amount produced by tumours with high or low pulmonary-colonization potential. These findings correlate well with our earlier morphological observations of marked connective tissue destruction in the vicinity of invading tumours and metastatic deposits, and indicate that protease release is implicated in the mechanism of tumour spread. IMAGES: Nature Publishing Group 1982-08 /pmc/articles/PMC2011086/ /pubmed/6295423 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Tarin, D.
Hoyt, B. J.
Evans, D. J.
Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.
title Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.
title_full Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.
title_fullStr Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.
title_full_unstemmed Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.
title_short Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.
title_sort correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011086/
https://www.ncbi.nlm.nih.gov/pubmed/6295423
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AT evansdj correlationofcollagenasesecretionwithmetastaticcolonizationpotentialinnaturallyoccurringmurinemammarytumours

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