Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.

Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism. In the present study, two specific inhibitors of...

Descripción completa

Detalles Bibliográficos
Autores principales: Tutton, P. J., Barkla, D. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011088/
https://www.ncbi.nlm.nih.gov/pubmed/6983886
_version_ 1782136458112401408
author Tutton, P. J.
Barkla, D. H.
author_facet Tutton, P. J.
Barkla, D. H.
author_sort Tutton, P. J.
collection PubMed
description Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism. In the present study, two specific inhibitors of serotonin uptake, Citalopram and Fluoxetine, are examined for their effects on cell proliferation and tumour growth. Each of the agents was found to suppress cell division in dimethylhydrazine-induced colonic tumours in rats, and to retard the growth of 2 out of 3 lines of human colonic tumours propagated as xenografts in immune-deprived mice.
format Text
id pubmed-2011088
institution National Center for Biotechnology Information
language English
publishDate 1982
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20110882009-09-10 Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas. Tutton, P. J. Barkla, D. H. Br J Cancer Research Article Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism. In the present study, two specific inhibitors of serotonin uptake, Citalopram and Fluoxetine, are examined for their effects on cell proliferation and tumour growth. Each of the agents was found to suppress cell division in dimethylhydrazine-induced colonic tumours in rats, and to retard the growth of 2 out of 3 lines of human colonic tumours propagated as xenografts in immune-deprived mice. Nature Publishing Group 1982-08 /pmc/articles/PMC2011088/ /pubmed/6983886 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Tutton, P. J.
Barkla, D. H.
Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
title Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
title_full Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
title_fullStr Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
title_full_unstemmed Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
title_short Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
title_sort influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011088/
https://www.ncbi.nlm.nih.gov/pubmed/6983886
work_keys_str_mv AT tuttonpj influenceofinhibitorsofserotoninuptakeonintestinalepitheliumandcolorectalcarcinomas
AT barkladh influenceofinhibitorsofserotoninuptakeonintestinalepitheliumandcolorectalcarcinomas

Ejemplares similares