Folate metabolism in man: the effect of malignant disease.

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding included the unchanged compound, other folates and a number of breakdown products, su...

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Autores principales: Saleh, A. M., Pheasant, A. E., Blair, J. A., Allan, R. N., Walters, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011131/
https://www.ncbi.nlm.nih.gov/pubmed/6982057
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author Saleh, A. M.
Pheasant, A. E.
Blair, J. A.
Allan, R. N.
Walters, J.
author_facet Saleh, A. M.
Pheasant, A. E.
Blair, J. A.
Allan, R. N.
Walters, J.
author_sort Saleh, A. M.
collection PubMed
description The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding included the unchanged compound, other folates and a number of breakdown products, such as p-acetamidobenzoyl-L-glutamate and p-acetamidobenzoate. This confirms the existence of a folate catabolic pathway in man. Patients with malignant disease excreted less of the dose in urine, incorporated more into the reduced folate pool, and showed decreased catabolism of folate, when compared to controls. 10-Formylfolate was excreted largely unchanged, and appears not to be reduced by man. Also 10-formylfolate interfered with the reduction of folic acid given simultaneously.
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spelling pubmed-20111312009-09-10 Folate metabolism in man: the effect of malignant disease. Saleh, A. M. Pheasant, A. E. Blair, J. A. Allan, R. N. Walters, J. Br J Cancer Research Article The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding included the unchanged compound, other folates and a number of breakdown products, such as p-acetamidobenzoyl-L-glutamate and p-acetamidobenzoate. This confirms the existence of a folate catabolic pathway in man. Patients with malignant disease excreted less of the dose in urine, incorporated more into the reduced folate pool, and showed decreased catabolism of folate, when compared to controls. 10-Formylfolate was excreted largely unchanged, and appears not to be reduced by man. Also 10-formylfolate interfered with the reduction of folic acid given simultaneously. Nature Publishing Group 1982-09 /pmc/articles/PMC2011131/ /pubmed/6982057 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Saleh, A. M.
Pheasant, A. E.
Blair, J. A.
Allan, R. N.
Walters, J.
Folate metabolism in man: the effect of malignant disease.
title Folate metabolism in man: the effect of malignant disease.
title_full Folate metabolism in man: the effect of malignant disease.
title_fullStr Folate metabolism in man: the effect of malignant disease.
title_full_unstemmed Folate metabolism in man: the effect of malignant disease.
title_short Folate metabolism in man: the effect of malignant disease.
title_sort folate metabolism in man: the effect of malignant disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011131/
https://www.ncbi.nlm.nih.gov/pubmed/6982057
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AT blairja folatemetabolisminmantheeffectofmalignantdisease
AT allanrn folatemetabolisminmantheeffectofmalignantdisease
AT waltersj folatemetabolisminmantheeffectofmalignantdisease

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