The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.

A new hypoxic cell radiosensitizer, Ro 03-8799, has been administered i.v. to 2 normal and 6 patient volunteers. Generally in non-necrotic tumours the concentrations obtained were 3 times greater than in plasma sampled at the same time. These observations added to the reports concerning toxicology i...

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Autores principales: Saunders, M. I., Dische, S., Fermont, D., Bishop, A., Lenox-Smith, I., Allen, J. G., Malcolm, S. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011152/
https://www.ncbi.nlm.nih.gov/pubmed/7171452
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author Saunders, M. I.
Dische, S.
Fermont, D.
Bishop, A.
Lenox-Smith, I.
Allen, J. G.
Malcolm, S. L.
author_facet Saunders, M. I.
Dische, S.
Fermont, D.
Bishop, A.
Lenox-Smith, I.
Allen, J. G.
Malcolm, S. L.
author_sort Saunders, M. I.
collection PubMed
description A new hypoxic cell radiosensitizer, Ro 03-8799, has been administered i.v. to 2 normal and 6 patient volunteers. Generally in non-necrotic tumours the concentrations obtained were 3 times greater than in plasma sampled at the same time. These observations added to the reports concerning toxicology in monkeys and rats and radiosensitizing efficiency in the laboratory, suggest that Ro 03-8799 may prove to be much more effective sensitizer than misonidazole in man.
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spelling pubmed-20111522009-09-10 The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study. Saunders, M. I. Dische, S. Fermont, D. Bishop, A. Lenox-Smith, I. Allen, J. G. Malcolm, S. L. Br J Cancer Research Article A new hypoxic cell radiosensitizer, Ro 03-8799, has been administered i.v. to 2 normal and 6 patient volunteers. Generally in non-necrotic tumours the concentrations obtained were 3 times greater than in plasma sampled at the same time. These observations added to the reports concerning toxicology in monkeys and rats and radiosensitizing efficiency in the laboratory, suggest that Ro 03-8799 may prove to be much more effective sensitizer than misonidazole in man. Nature Publishing Group 1982-11 /pmc/articles/PMC2011152/ /pubmed/7171452 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Saunders, M. I.
Dische, S.
Fermont, D.
Bishop, A.
Lenox-Smith, I.
Allen, J. G.
Malcolm, S. L.
The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
title The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
title_full The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
title_fullStr The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
title_full_unstemmed The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
title_short The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
title_sort radiosensitizer ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011152/
https://www.ncbi.nlm.nih.gov/pubmed/7171452
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