Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.

ICRF-187 was tested for cardioprotective activity in doxorubicin-treated mice and guinea pigs. Pretreatment with i.p. ICRF-187 caused a significant decrease in the indicence of i.v. doxorubicin-induced myocardial histological damage in the mouse. I.p. ICRF-187 did not, however, reduce the effect of...

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Autores principales: Perkins, W. E., Schroeder, R. L., Carrano, R. A., Imondi, A. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011185/
https://www.ncbi.nlm.nih.gov/pubmed/6814473
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author Perkins, W. E.
Schroeder, R. L.
Carrano, R. A.
Imondi, A. R.
author_facet Perkins, W. E.
Schroeder, R. L.
Carrano, R. A.
Imondi, A. R.
author_sort Perkins, W. E.
collection PubMed
description ICRF-187 was tested for cardioprotective activity in doxorubicin-treated mice and guinea pigs. Pretreatment with i.p. ICRF-187 caused a significant decrease in the indicence of i.v. doxorubicin-induced myocardial histological damage in the mouse. I.p. ICRF-187 did not, however, reduce the effect of i.p. doxorubicin on a functional myocardial effect of this antitumour drug, a reduced histamine responsiveness of right atria in vitro. These data suggest that ICRF-187 may not be specific for all the cardiac effects of doxorubicin.
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spelling pubmed-20111852009-09-10 Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig. Perkins, W. E. Schroeder, R. L. Carrano, R. A. Imondi, A. R. Br J Cancer Research Article ICRF-187 was tested for cardioprotective activity in doxorubicin-treated mice and guinea pigs. Pretreatment with i.p. ICRF-187 caused a significant decrease in the indicence of i.v. doxorubicin-induced myocardial histological damage in the mouse. I.p. ICRF-187 did not, however, reduce the effect of i.p. doxorubicin on a functional myocardial effect of this antitumour drug, a reduced histamine responsiveness of right atria in vitro. These data suggest that ICRF-187 may not be specific for all the cardiac effects of doxorubicin. Nature Publishing Group 1982-10 /pmc/articles/PMC2011185/ /pubmed/6814473 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Perkins, W. E.
Schroeder, R. L.
Carrano, R. A.
Imondi, A. R.
Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.
title Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.
title_full Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.
title_fullStr Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.
title_full_unstemmed Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.
title_short Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.
title_sort effect of icrf-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011185/
https://www.ncbi.nlm.nih.gov/pubmed/6814473
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AT carranora effectoficrf187ondoxorubicininducedmyocardialeffectsinthemouseandguineapig
AT imondiar effectoficrf187ondoxorubicininducedmyocardialeffectsinthemouseandguineapig

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