The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.

We have measured post-irradiation recovery (potentially lethal damage repair) after fractionated radiation in plateau-phase cultures of two human tumour cell lines derived from tumours of different radiocurabilities (melanoma and breast). Although the radiation survival-curve parameters of these cel...

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Detalles Bibliográficos
Autores principales: Weichselbaum, R. R., Little, J. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011194/
https://www.ncbi.nlm.nih.gov/pubmed/7138762
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author Weichselbaum, R. R.
Little, J. B.
author_facet Weichselbaum, R. R.
Little, J. B.
author_sort Weichselbaum, R. R.
collection PubMed
description We have measured post-irradiation recovery (potentially lethal damage repair) after fractionated radiation in plateau-phase cultures of two human tumour cell lines derived from tumours of different radiocurabilities (melanoma and breast). Although the radiation survival-curve parameters of these cell lines are similar, the repair of potentially lethal X-ray damage after fractionated X-ray treatment conferred significant radioresistance on the human melanoma cells but not the human breast carcinoma cells. We suggest that the repair of potentially lethal damage may correlate with clinical radiocurability.
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spelling pubmed-20111942009-09-10 The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process. Weichselbaum, R. R. Little, J. B. Br J Cancer Research Article We have measured post-irradiation recovery (potentially lethal damage repair) after fractionated radiation in plateau-phase cultures of two human tumour cell lines derived from tumours of different radiocurabilities (melanoma and breast). Although the radiation survival-curve parameters of these cell lines are similar, the repair of potentially lethal X-ray damage after fractionated X-ray treatment conferred significant radioresistance on the human melanoma cells but not the human breast carcinoma cells. We suggest that the repair of potentially lethal damage may correlate with clinical radiocurability. Nature Publishing Group 1982-10 /pmc/articles/PMC2011194/ /pubmed/7138762 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Weichselbaum, R. R.
Little, J. B.
The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
title The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
title_full The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
title_fullStr The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
title_full_unstemmed The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
title_short The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
title_sort differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011194/
https://www.ncbi.nlm.nih.gov/pubmed/7138762
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