Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study

The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate—below 10% in 221 patients—permits continuation of the intake, w...

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Detalles Bibliográficos
Autores principales: Balslev, I., Pedersen, M., Teglbjaerg, P. S., Hanberg-Sørensen, F., Bone, J., Jacobsen, N. O., Overgaard, J., Sell, A., Bertelsen, K., Hage, E., Hansen, L., Kronborg, O., Høstrup, H., Nørgaard-Pedersen, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011200/
https://www.ncbi.nlm.nih.gov/pubmed/6753912
Descripción
Sumario:The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate—below 10% in 221 patients—permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90.

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