Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study

The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate—below 10% in 221 patients—permits continuation of the intake, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Balslev, I., Pedersen, M., Teglbjaerg, P. S., Hanberg-Sørensen, F., Bone, J., Jacobsen, N. O., Overgaard, J., Sell, A., Bertelsen, K., Hage, E., Hansen, L., Kronborg, O., Høstrup, H., Nørgaard-Pedersen, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011200/
https://www.ncbi.nlm.nih.gov/pubmed/6753912
_version_ 1782136481664466944
author Balslev, I.
Pedersen, M.
Teglbjaerg, P. S.
Hanberg-Sørensen, F.
Bone, J.
Jacobsen, N. O.
Overgaard, J.
Sell, A.
Bertelsen, K.
Hage, E.
Hansen, L.
Kronborg, O.
Høstrup, H.
Nørgaard-Pedersen, B.
author_facet Balslev, I.
Pedersen, M.
Teglbjaerg, P. S.
Hanberg-Sørensen, F.
Bone, J.
Jacobsen, N. O.
Overgaard, J.
Sell, A.
Bertelsen, K.
Hage, E.
Hansen, L.
Kronborg, O.
Høstrup, H.
Nørgaard-Pedersen, B.
author_sort Balslev, I.
collection PubMed
description The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate—below 10% in 221 patients—permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90.
format Text
id pubmed-2011200
institution National Center for Biotechnology Information
language English
publishDate 1982
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20112002009-09-10 Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study Balslev, I. Pedersen, M. Teglbjaerg, P. S. Hanberg-Sørensen, F. Bone, J. Jacobsen, N. O. Overgaard, J. Sell, A. Bertelsen, K. Hage, E. Hansen, L. Kronborg, O. Høstrup, H. Nørgaard-Pedersen, B. Br J Cancer Articles The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate—below 10% in 221 patients—permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90. Nature Publishing Group 1982-10 /pmc/articles/PMC2011200/ /pubmed/6753912 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Balslev, I.
Pedersen, M.
Teglbjaerg, P. S.
Hanberg-Sørensen, F.
Bone, J.
Jacobsen, N. O.
Overgaard, J.
Sell, A.
Bertelsen, K.
Hage, E.
Hansen, L.
Kronborg, O.
Høstrup, H.
Nørgaard-Pedersen, B.
Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study
title Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study
title_full Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study
title_fullStr Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study
title_full_unstemmed Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study
title_short Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: Interim report from a randomized multicentre study
title_sort postoperative radiotherapy in rectosigmoid cancer dukes' b and c: interim report from a randomized multicentre study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011200/
https://www.ncbi.nlm.nih.gov/pubmed/6753912
work_keys_str_mv AT balslevi postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT pedersenm postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT teglbjaergps postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT hanbergsørensenf postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT bonej postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT jacobsenno postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT overgaardj postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT sella postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT bertelsenk postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT hagee postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT hansenl postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT kronborgo postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT høstruph postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy
AT nørgaardpedersenb postoperativeradiotherapyinrectosigmoidcancerdukesbandcinterimreportfromarandomizedmulticentrestudy

Ejemplares similares