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Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo.
The importance of the priming heat treatment temperature and heating time for the degree and kinetics of thermotolerance was investigated in a C3H mammary carcinoma inoculated into the feet of CDF1 mice. A single heat treatment in the range 41.5-44.5 degrees C resulted in a linear relationship betwe...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1982
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011232/ https://www.ncbi.nlm.nih.gov/pubmed/7150483 |
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author | Nielsen, O. S. Overgaard, J. |
author_facet | Nielsen, O. S. Overgaard, J. |
author_sort | Nielsen, O. S. |
collection | PubMed |
description | The importance of the priming heat treatment temperature and heating time for the degree and kinetics of thermotolerance was investigated in a C3H mammary carcinoma inoculated into the feet of CDF1 mice. A single heat treatment in the range 41.5-44.5 degrees C resulted in a linear relationship between heating time and tumour growth time (i.e. the time for tumours to reach a volume five times that of the first treatment day). An Arrhenius plot showed an inflection point at 42.5 degrees C with activation energies of 635 and 1508 kJ/mol, respectively, above and below 42.5 degrees C. The degree and kinetics of thermotolerance were independent of the preheating temperature, if the heating time was adjusted to give the same level of heat damage. A pretreatment at these temperatures with a tumour growth time of approximately 10 days, equivalent to 30 min at 43.5 degrees C, resulted in maximal thermotolerance at a 16-h interval with a thermotolerance ratio (TTRmax) of approximately 5.2. Preheating of the tumours at 43.5 degrees C for 3.5, 7.5, 15, 30, or 45 min, showed that if the preheating time was increased, both the TTRmax and the time interval necessary to develop TTRmax increased, both being linear functions of the duration of the preheating time. Maximal thermotolerance was obtained at intervals of 2, 4, 8, 16, and 28 h with TTRmax of 1.6, 2.2, 3.7, 5.2, and 7.7, respectively. |
format | Text |
id | pubmed-2011232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1982 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20112322009-09-10 Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. Nielsen, O. S. Overgaard, J. Br J Cancer Research Article The importance of the priming heat treatment temperature and heating time for the degree and kinetics of thermotolerance was investigated in a C3H mammary carcinoma inoculated into the feet of CDF1 mice. A single heat treatment in the range 41.5-44.5 degrees C resulted in a linear relationship between heating time and tumour growth time (i.e. the time for tumours to reach a volume five times that of the first treatment day). An Arrhenius plot showed an inflection point at 42.5 degrees C with activation energies of 635 and 1508 kJ/mol, respectively, above and below 42.5 degrees C. The degree and kinetics of thermotolerance were independent of the preheating temperature, if the heating time was adjusted to give the same level of heat damage. A pretreatment at these temperatures with a tumour growth time of approximately 10 days, equivalent to 30 min at 43.5 degrees C, resulted in maximal thermotolerance at a 16-h interval with a thermotolerance ratio (TTRmax) of approximately 5.2. Preheating of the tumours at 43.5 degrees C for 3.5, 7.5, 15, 30, or 45 min, showed that if the preheating time was increased, both the TTRmax and the time interval necessary to develop TTRmax increased, both being linear functions of the duration of the preheating time. Maximal thermotolerance was obtained at intervals of 2, 4, 8, 16, and 28 h with TTRmax of 1.6, 2.2, 3.7, 5.2, and 7.7, respectively. Nature Publishing Group 1982-12 /pmc/articles/PMC2011232/ /pubmed/7150483 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Nielsen, O. S. Overgaard, J. Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. |
title | Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. |
title_full | Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. |
title_fullStr | Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. |
title_full_unstemmed | Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. |
title_short | Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. |
title_sort | importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011232/ https://www.ncbi.nlm.nih.gov/pubmed/7150483 |
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