Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.

Lonidamine or 1-[(2, 4-dichlorophenyl) methyl]-1H-indazole-3-carboxylic acid, studied in a battery of in vitro and in vivo tests currently used for the screening of anti-tumour agents affecting cell division, has been shown to have a narrow spectrum of anti-tumour activity. The significance of this...

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Autores principales: Silvestrini, B., Hahn, G. M., Cioli, V., De Martino, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011275/
https://www.ncbi.nlm.nih.gov/pubmed/6824568
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author Silvestrini, B.
Hahn, G. M.
Cioli, V.
De Martino, C.
author_facet Silvestrini, B.
Hahn, G. M.
Cioli, V.
De Martino, C.
author_sort Silvestrini, B.
collection PubMed
description Lonidamine or 1-[(2, 4-dichlorophenyl) methyl]-1H-indazole-3-carboxylic acid, studied in a battery of in vitro and in vivo tests currently used for the screening of anti-tumour agents affecting cell division, has been shown to have a narrow spectrum of anti-tumour activity. The significance of this finding is discussed in the light of previous investigations suggesting that lonidamine affects mitochondrial function and not cell replication. Hyperthermia has been shown to sensitize tumour cells to lonidamine. This observation indicates that in combination with hyperthermia lonidamine has some potential for the treatment of cancer; moreover, it suggests that hyperthermia might reproduce a metabolic condition occurring in some stages of the disease. The blood levels corresponding to the anti-tumour action of lonidamine in animals are in the range of those detected in patients treated with the drug. IMAGES:
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spelling pubmed-20112752009-09-10 Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems. Silvestrini, B. Hahn, G. M. Cioli, V. De Martino, C. Br J Cancer Research Article Lonidamine or 1-[(2, 4-dichlorophenyl) methyl]-1H-indazole-3-carboxylic acid, studied in a battery of in vitro and in vivo tests currently used for the screening of anti-tumour agents affecting cell division, has been shown to have a narrow spectrum of anti-tumour activity. The significance of this finding is discussed in the light of previous investigations suggesting that lonidamine affects mitochondrial function and not cell replication. Hyperthermia has been shown to sensitize tumour cells to lonidamine. This observation indicates that in combination with hyperthermia lonidamine has some potential for the treatment of cancer; moreover, it suggests that hyperthermia might reproduce a metabolic condition occurring in some stages of the disease. The blood levels corresponding to the anti-tumour action of lonidamine in animals are in the range of those detected in patients treated with the drug. IMAGES: Nature Publishing Group 1983-02 /pmc/articles/PMC2011275/ /pubmed/6824568 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Silvestrini, B.
Hahn, G. M.
Cioli, V.
De Martino, C.
Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
title Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
title_full Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
title_fullStr Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
title_full_unstemmed Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
title_short Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
title_sort effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011275/
https://www.ncbi.nlm.nih.gov/pubmed/6824568
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