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Human lymphoblastoid interferon in the treatment of small cell lung cancer.

Ten patients with small cell lung cancer were treated with high dose human lymphoblastoid interferon (50-100 megaunits m-2) for 5 days, followed by low dose interferon (3 megaunits m-2) for 3 weeks. At the end of treatment, and one month later, there was no evidence of either complete or partial res...

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Autores principales: Jones, D. H., Bleehen, N. M., Slater, A. J., George, P. J., Walker, J. R., Dixon, A. K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011299/
https://www.ncbi.nlm.nih.gov/pubmed/6299317
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author Jones, D. H.
Bleehen, N. M.
Slater, A. J.
George, P. J.
Walker, J. R.
Dixon, A. K.
author_facet Jones, D. H.
Bleehen, N. M.
Slater, A. J.
George, P. J.
Walker, J. R.
Dixon, A. K.
author_sort Jones, D. H.
collection PubMed
description Ten patients with small cell lung cancer were treated with high dose human lymphoblastoid interferon (50-100 megaunits m-2) for 5 days, followed by low dose interferon (3 megaunits m-2) for 3 weeks. At the end of treatment, and one month later, there was no evidence of either complete or partial response. The treatment produced fever, anorexia and weight loss, with transient leucopenia and thrombocytopenia; there was evidence of a non-cholestatic elevation of serum alanine aminotransferase, with clinical deterioration in the condition of three patients presenting with hyponatraemia. A transient hypocalcaemia during high dose therapy was also noted. It seems that lymphoblastoid interferon as a single agent is unlikely to have a role in the treatment of small cell lung cancer, and that its administration as employed in this study is associated with considerable toxicity.
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spelling pubmed-20112992009-09-10 Human lymphoblastoid interferon in the treatment of small cell lung cancer. Jones, D. H. Bleehen, N. M. Slater, A. J. George, P. J. Walker, J. R. Dixon, A. K. Br J Cancer Research Article Ten patients with small cell lung cancer were treated with high dose human lymphoblastoid interferon (50-100 megaunits m-2) for 5 days, followed by low dose interferon (3 megaunits m-2) for 3 weeks. At the end of treatment, and one month later, there was no evidence of either complete or partial response. The treatment produced fever, anorexia and weight loss, with transient leucopenia and thrombocytopenia; there was evidence of a non-cholestatic elevation of serum alanine aminotransferase, with clinical deterioration in the condition of three patients presenting with hyponatraemia. A transient hypocalcaemia during high dose therapy was also noted. It seems that lymphoblastoid interferon as a single agent is unlikely to have a role in the treatment of small cell lung cancer, and that its administration as employed in this study is associated with considerable toxicity. Nature Publishing Group 1983-03 /pmc/articles/PMC2011299/ /pubmed/6299317 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jones, D. H.
Bleehen, N. M.
Slater, A. J.
George, P. J.
Walker, J. R.
Dixon, A. K.
Human lymphoblastoid interferon in the treatment of small cell lung cancer.
title Human lymphoblastoid interferon in the treatment of small cell lung cancer.
title_full Human lymphoblastoid interferon in the treatment of small cell lung cancer.
title_fullStr Human lymphoblastoid interferon in the treatment of small cell lung cancer.
title_full_unstemmed Human lymphoblastoid interferon in the treatment of small cell lung cancer.
title_short Human lymphoblastoid interferon in the treatment of small cell lung cancer.
title_sort human lymphoblastoid interferon in the treatment of small cell lung cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011299/
https://www.ncbi.nlm.nih.gov/pubmed/6299317
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