Investigations of tissue folates in normal and malignant tissues.

The folates present in liver, gut and tumour tissue were examined before and after autolysis. Before autolysis 10-formylfolate tetraglutamate (10-CHOFA(glu)4), 5-methyltetrahydrofolate triglutamate (5-CH3THF(glu)3) and possibly tetrahydrofolate polyglutamate(s) (THF(glu)n) were detected. Liver conta...

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Autores principales: Pheasant, A. E., Bates, J., Blair, J. A., Nayyir-Mazhir, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011316/
https://www.ncbi.nlm.nih.gov/pubmed/6830689
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author Pheasant, A. E.
Bates, J.
Blair, J. A.
Nayyir-Mazhir, R.
author_facet Pheasant, A. E.
Bates, J.
Blair, J. A.
Nayyir-Mazhir, R.
author_sort Pheasant, A. E.
collection PubMed
description The folates present in liver, gut and tumour tissue were examined before and after autolysis. Before autolysis 10-formylfolate tetraglutamate (10-CHOFA(glu)4), 5-methyltetrahydrofolate triglutamate (5-CH3THF(glu)3) and possibly tetrahydrofolate polyglutamate(s) (THF(glu)n) were detected. Liver contained all 3 species whereas no 5-CH3THF(glu)3 was present in the tumours; gut showed an intermediate situation. After autolysis the predominant monoglutamates formed were 5-CH3THF in the liver, 10-formylfolates in the gut and possibly tetrahydrofolate (THF) in the tumour extracts. These differences illustrate changes in tissue folates with the proliferation rate of the tissue and suggest an explanation for the methionine auxotrophy of Walker 256 carcinosarcoma cells.
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spelling pubmed-20113162009-09-10 Investigations of tissue folates in normal and malignant tissues. Pheasant, A. E. Bates, J. Blair, J. A. Nayyir-Mazhir, R. Br J Cancer Research Article The folates present in liver, gut and tumour tissue were examined before and after autolysis. Before autolysis 10-formylfolate tetraglutamate (10-CHOFA(glu)4), 5-methyltetrahydrofolate triglutamate (5-CH3THF(glu)3) and possibly tetrahydrofolate polyglutamate(s) (THF(glu)n) were detected. Liver contained all 3 species whereas no 5-CH3THF(glu)3 was present in the tumours; gut showed an intermediate situation. After autolysis the predominant monoglutamates formed were 5-CH3THF in the liver, 10-formylfolates in the gut and possibly tetrahydrofolate (THF) in the tumour extracts. These differences illustrate changes in tissue folates with the proliferation rate of the tissue and suggest an explanation for the methionine auxotrophy of Walker 256 carcinosarcoma cells. Nature Publishing Group 1983-03 /pmc/articles/PMC2011316/ /pubmed/6830689 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pheasant, A. E.
Bates, J.
Blair, J. A.
Nayyir-Mazhir, R.
Investigations of tissue folates in normal and malignant tissues.
title Investigations of tissue folates in normal and malignant tissues.
title_full Investigations of tissue folates in normal and malignant tissues.
title_fullStr Investigations of tissue folates in normal and malignant tissues.
title_full_unstemmed Investigations of tissue folates in normal and malignant tissues.
title_short Investigations of tissue folates in normal and malignant tissues.
title_sort investigations of tissue folates in normal and malignant tissues.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011316/
https://www.ncbi.nlm.nih.gov/pubmed/6830689
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AT nayyirmazhirr investigationsoftissuefolatesinnormalandmalignanttissues

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