Prognostic significance of serum prolactin levels in advanced breast cancer.

Serum prolactin concentrations were measured in 135 postmenopausal patients with advanced breast cancer prior to their treatment with one of 3 endocrine therapies: aminoglutethimide (AG), tamoxifen (T) + AG, or T + AG + danazol. The mean level of prolactin was higher, and there were more individuals...

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Autores principales: Dowsett, M., McGarrick, G. E., Harris, A. L., Coombes, R. C., Smith, I. E., Jeffcoate, S. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011370/
https://www.ncbi.nlm.nih.gov/pubmed/6860546
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author Dowsett, M.
McGarrick, G. E.
Harris, A. L.
Coombes, R. C.
Smith, I. E.
Jeffcoate, S. L.
author_facet Dowsett, M.
McGarrick, G. E.
Harris, A. L.
Coombes, R. C.
Smith, I. E.
Jeffcoate, S. L.
author_sort Dowsett, M.
collection PubMed
description Serum prolactin concentrations were measured in 135 postmenopausal patients with advanced breast cancer prior to their treatment with one of 3 endocrine therapies: aminoglutethimide (AG), tamoxifen (T) + AG, or T + AG + danazol. The mean level of prolactin was higher, and there were more individuals with levels of prolactin greater than or equal to 500 mIUl-1, in the group of patients who did not respond to treatment. Of the patients whose disease progressed, those with prolactin levels greater than or equal to 500 mIUl-1 had a significantly shorter survival. It appears that high prolactin levels indicate a poor prognosis to endocrine therapy and the probability of a shorter than average survival time.
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spelling pubmed-20113702009-09-10 Prognostic significance of serum prolactin levels in advanced breast cancer. Dowsett, M. McGarrick, G. E. Harris, A. L. Coombes, R. C. Smith, I. E. Jeffcoate, S. L. Br J Cancer Research Article Serum prolactin concentrations were measured in 135 postmenopausal patients with advanced breast cancer prior to their treatment with one of 3 endocrine therapies: aminoglutethimide (AG), tamoxifen (T) + AG, or T + AG + danazol. The mean level of prolactin was higher, and there were more individuals with levels of prolactin greater than or equal to 500 mIUl-1, in the group of patients who did not respond to treatment. Of the patients whose disease progressed, those with prolactin levels greater than or equal to 500 mIUl-1 had a significantly shorter survival. It appears that high prolactin levels indicate a poor prognosis to endocrine therapy and the probability of a shorter than average survival time. Nature Publishing Group 1983-06 /pmc/articles/PMC2011370/ /pubmed/6860546 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dowsett, M.
McGarrick, G. E.
Harris, A. L.
Coombes, R. C.
Smith, I. E.
Jeffcoate, S. L.
Prognostic significance of serum prolactin levels in advanced breast cancer.
title Prognostic significance of serum prolactin levels in advanced breast cancer.
title_full Prognostic significance of serum prolactin levels in advanced breast cancer.
title_fullStr Prognostic significance of serum prolactin levels in advanced breast cancer.
title_full_unstemmed Prognostic significance of serum prolactin levels in advanced breast cancer.
title_short Prognostic significance of serum prolactin levels in advanced breast cancer.
title_sort prognostic significance of serum prolactin levels in advanced breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011370/
https://www.ncbi.nlm.nih.gov/pubmed/6860546
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