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Paradoxical response of malignant melanoma to methotrexate in vivo and in vitro.

Methotrexate (MTX) shows consistent cytotoxicity for melanoma cells in vitro but it is ineffective in clinical use at equivalent concentrations in vivo. This apparent paradox has been investigated by cell culture techniques and results quantified by cell number. In an in vitro model of high dose MTX...

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Detalles Bibliográficos
Autores principales:	Gaukroger, J., Wilson, L., Stewart, M., Farid, Y., Habeshaw, T., Harding, N., Mackie, R.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1983
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011395/ https://www.ncbi.nlm.nih.gov/pubmed/6601959

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