The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.

The possible effect of lithium chloride, a compound which reduces the incidence of infection in cancer patients, was investigated on murine melanoma. C57 BL syngeneic mice were inoculated i.p. with B16 melanoma cells. The animals were divided into 4 groups, receiving daily i.p. treatment with saline...

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Autores principales: Ballin, A., Aladjem, M., Banyash, M., Boichis, H., Barzilay, Z., Gal, R., Witz, I. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011407/
https://www.ncbi.nlm.nih.gov/pubmed/6191768
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author Ballin, A.
Aladjem, M.
Banyash, M.
Boichis, H.
Barzilay, Z.
Gal, R.
Witz, I. P.
author_facet Ballin, A.
Aladjem, M.
Banyash, M.
Boichis, H.
Barzilay, Z.
Gal, R.
Witz, I. P.
author_sort Ballin, A.
collection PubMed
description The possible effect of lithium chloride, a compound which reduces the incidence of infection in cancer patients, was investigated on murine melanoma. C57 BL syngeneic mice were inoculated i.p. with B16 melanoma cells. The animals were divided into 4 groups, receiving daily i.p. treatment with saline--group 1, controls; lithium chloride--group 2, bleomycin and vinblastine--group 3, and lithium chloride with bleomycin and vinblastine--group 4. Animals in group 4 had a significant delay in tumour appearance, a higher degree of tumour necrosis, and a longer survival rate. In addition a significant reduction of serum lithium concentration was noted in animals of this group in comparison with animals in group 2, treated with lithium chloride alone. There was no lithium-induced leukocytosis.
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spelling pubmed-20114072009-09-10 The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice. Ballin, A. Aladjem, M. Banyash, M. Boichis, H. Barzilay, Z. Gal, R. Witz, I. P. Br J Cancer Research Article The possible effect of lithium chloride, a compound which reduces the incidence of infection in cancer patients, was investigated on murine melanoma. C57 BL syngeneic mice were inoculated i.p. with B16 melanoma cells. The animals were divided into 4 groups, receiving daily i.p. treatment with saline--group 1, controls; lithium chloride--group 2, bleomycin and vinblastine--group 3, and lithium chloride with bleomycin and vinblastine--group 4. Animals in group 4 had a significant delay in tumour appearance, a higher degree of tumour necrosis, and a longer survival rate. In addition a significant reduction of serum lithium concentration was noted in animals of this group in comparison with animals in group 2, treated with lithium chloride alone. There was no lithium-induced leukocytosis. Nature Publishing Group 1983-07 /pmc/articles/PMC2011407/ /pubmed/6191768 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ballin, A.
Aladjem, M.
Banyash, M.
Boichis, H.
Barzilay, Z.
Gal, R.
Witz, I. P.
The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.
title The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.
title_full The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.
title_fullStr The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.
title_full_unstemmed The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.
title_short The effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.
title_sort effect of lithium chloride on tumour appearance and survival of melanoma-bearing mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011407/
https://www.ncbi.nlm.nih.gov/pubmed/6191768
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