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Clinical correlates of in vitro drug sensitivities of ovarian cancer cells.

Of 89 samples of cancer cells from ovarian cancer patients primary cultures representative of the cancer cell population could be established in 17. The clinical response to polychemotherapy was studied in relation to the inhibition of thymidine uptake by the cultured cells. Cultures of each patient...

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Autores principales: Morasca, L., Erba, E., Vaghi, M., Ghelardoni, C., Mangioni, C., Sessa, C., Landoni, F., Garattini, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011415/
https://www.ncbi.nlm.nih.gov/pubmed/6409137
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author Morasca, L.
Erba, E.
Vaghi, M.
Ghelardoni, C.
Mangioni, C.
Sessa, C.
Landoni, F.
Garattini, S.
author_facet Morasca, L.
Erba, E.
Vaghi, M.
Ghelardoni, C.
Mangioni, C.
Sessa, C.
Landoni, F.
Garattini, S.
author_sort Morasca, L.
collection PubMed
description Of 89 samples of cancer cells from ovarian cancer patients primary cultures representative of the cancer cell population could be established in 17. The clinical response to polychemotherapy was studied in relation to the inhibition of thymidine uptake by the cultured cells. Cultures of each patient's tumour were exposed to concentrations of the drugs the patients had been given for long enough to reproduce the area under the curve (AUC) of the plasma levels resulting from in vivo dosage. Full agreement was observed between the degree of thymidine uptake inhibition induced by at least one of the drugs administered to the cultured cells and the degree of clinical response. This approach may prove useful in pharmacological studies as a means of obtaining ovarian cancer cell populations representative of human tumours, even though the number of tumours that can be successfully evaluated in vitro is still too small to serve as a sound basis for prediction. IMAGES:
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spelling pubmed-20114152009-09-10 Clinical correlates of in vitro drug sensitivities of ovarian cancer cells. Morasca, L. Erba, E. Vaghi, M. Ghelardoni, C. Mangioni, C. Sessa, C. Landoni, F. Garattini, S. Br J Cancer Research Article Of 89 samples of cancer cells from ovarian cancer patients primary cultures representative of the cancer cell population could be established in 17. The clinical response to polychemotherapy was studied in relation to the inhibition of thymidine uptake by the cultured cells. Cultures of each patient's tumour were exposed to concentrations of the drugs the patients had been given for long enough to reproduce the area under the curve (AUC) of the plasma levels resulting from in vivo dosage. Full agreement was observed between the degree of thymidine uptake inhibition induced by at least one of the drugs administered to the cultured cells and the degree of clinical response. This approach may prove useful in pharmacological studies as a means of obtaining ovarian cancer cell populations representative of human tumours, even though the number of tumours that can be successfully evaluated in vitro is still too small to serve as a sound basis for prediction. IMAGES: Nature Publishing Group 1983-07 /pmc/articles/PMC2011415/ /pubmed/6409137 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Morasca, L.
Erba, E.
Vaghi, M.
Ghelardoni, C.
Mangioni, C.
Sessa, C.
Landoni, F.
Garattini, S.
Clinical correlates of in vitro drug sensitivities of ovarian cancer cells.
title Clinical correlates of in vitro drug sensitivities of ovarian cancer cells.
title_full Clinical correlates of in vitro drug sensitivities of ovarian cancer cells.
title_fullStr Clinical correlates of in vitro drug sensitivities of ovarian cancer cells.
title_full_unstemmed Clinical correlates of in vitro drug sensitivities of ovarian cancer cells.
title_short Clinical correlates of in vitro drug sensitivities of ovarian cancer cells.
title_sort clinical correlates of in vitro drug sensitivities of ovarian cancer cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011415/
https://www.ncbi.nlm.nih.gov/pubmed/6409137
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